Prediction of successful stroke rehabiliation outcome by functional connectivity

Prediction of successful stroke rehabiliation outcome by functional connectivity - Reha-Conn

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00014642

Enrollment

Registered

2018-04-20

Start date

2017-09-06

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I63.5

Interventions

Group 1: Patients with a stroke On days 4-7 after the scarfing incident: MRI including fMRI, Resting state before and after Sequence learning paradigm, T1 measurement physical examination (RASP, Fugl

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: stroke in the previous 7 days resulting in motor deficits in the upper extremity

Exclusion criteria

Exclusion criteria: complete motor recovery during inpatient stay, limited understanding/ co-ability, previous cerebral ischemia, contraindications to MRI, unstable clinical situation

Design outcomes

Primary

Measure	Time frame
Correlation and thus prognosis prediction between short-term learning-associated functional connectivity changes in the motor cerebral system and the individual rehabilitation outcome. The MRI, which is crucial for the prognosis, is performed during the stay in the acute hospital (days 4-7 after stroke). The change in functional connectivity is measured between 2 resting state measurements performed before and after a 12-minute sequence learning paradigm. Motor outcome is the result of the Fugl-Meyer assessment scores after 6 months. In short: Prediction of motor stroke outcome (Fugl Meyer score 6 months post stroke) of mean initally measured changes in functional connectivity induced by a 12 minute sequence learning paradigm.	—

Measure

Time frame

Correlation and thus prognosis prediction between short-term learning-associated functional connectivity changes in the motor cerebral system and the individual rehabilitation outcome. The MRI, which is crucial for the prognosis, is performed during the stay in the acute hospital (days 4-7 after stroke). The change in functional connectivity is measured between 2 resting state measurements performed before and after a 12-minute sequence learning paradigm. Motor outcome is the result of the Fugl-Meyer assessment scores after 6 months. In short: Prediction of motor stroke outcome (Fugl Meyer score 6 months post stroke) of mean initally measured changes in functional connectivity induced by a 12 minute sequence learning paradigm.

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Secondary

Measure	Time frame
Association of the connectivity described in the primary endpoint with the following scores: RASP, NHPT, HADS, BSQ.	—

Countries

Germany

Contacts

Public ContactCarsten Klingner

Jena, Universitätsklinik, Abteilung für Neurologie

carsten.klingner@med.uni-jena.de03641 9323450

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026