Sepsis A41
Conditions
Interventions
Group 1: ICU patients with sepsis, SOFA-Score 2-3
Analysis and characterization of extensive sepsis-related parameters, inflammatory mediators, predisposing factors as well as the immune response taking into account the clinical severity of underlyin
Sponsors
Universitätsklinikum Hamburg-EppendorfKlinik für Intensivmedizin
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients in an intensive care unit suspected or diagnosed with sepsis according to the Sepsis 3 Definition
Exclusion criteria
Exclusion criteria: Cardiogenic shock, pregnancy or lactation, lack of consent, moribund state
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum and plasma levels of various cytokines / chemokines including differentiated analysis of immune cells as well as mRNA and DNA, which are subject to regulation at expression level (mRNA / DNA). Explicit, there is no analysis of the genome or chromosomal changes. | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of sepsis, 28d-mortality and mortality in intensive care; also clinical parameters such as ventilation days and need for dialysis | — |
Countries
Germany
Contacts
Public ContactAxel Nierhaus
Universitätsklinikum Hamburg-EppendorfKlinik für Intensivmedizin
Outcome results
None listed