Influence of mechanical ventilation on the pharmacocinetics of desflurane and sevoflurane

Influence of mechanical ventilation on the pharmacocinetics of desflurane and sevoflurane - Respiratory mechanics and pharmacikinetic

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00014575

Enrollment

Registered

2018-06-07

Start date

2018-05-03

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

READING AND EVALUATION OF VENTILATION PARAMETERS AND ANAESTHETIC GAS MEASUREMENTS

Interventions

Group 1: Participants of this study are patients undergoing an elective surgical procedure. The precondition for the participation is the prior written consent. Record of ventilation parameters and co

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Written consent of the patient, age =18 years, American Society of Anesthesiologists (ASA) 1-2.

Exclusion criteria

Exclusion criteria: ASA >2, Age <18, pulmonray disease, pregnancy.

Design outcomes

Primary

Measure	Time frame
Decrement-times of desflurane and sevoflurane (.9, .8, .7,...,.1 MAC).	—

Secondary

Measure	Time frame
Mechanical ventilation settings, duration of general anaesthesia, patient data, measurement of ins- and exspiratory gas fraction of volatile anesthetics.	—

Countries

Germany

Contacts

Public ContactSteffen Wirth

Klinik für Anästhesiologie und Intensivmedizin Universitätsklinikum Freiburg

steffen.wirth@uniklinik-freiburg.de076127023060

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026