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Neurobiological mechanisms of early mother-infant-bonding

Neurobiological mechanisms of early mother-infant-bonding - NeMuK

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
DRKS
Registry ID
DRKS00014570
Enrollment
80
Registered
2018-04-06
Start date
2018-01-30
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postpartum Bonding Disorder F53

Interventions

Group 1: - fMRI Neurofeedback of ventral striatum activity for women with postpartum bonding difficulties (3 sessions in 4th month postpartum) - Assessment of maternal bonding, MRI response patterns,

Sponsors

Institut fuer Medizinische Psychologie im Zentrum fuer Psychosoziale Medizin (ZPM)UniversitaetsKlinikum Heidelberg
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Mothers who gave birth to a healthy child within the last 3-4 month and report problems in bonding with the child. Depressive symptoms are not an exclusion criteria. Healthy controls: Mentally healthy mothers who gave birth to a healthy child within the last 3-4 month and report good bonding with the child Fathers of the participating infants who give informed content.

Exclusion criteria

Exclusion criteria: acute suicidality, bipolare disorder, schizophrenia, dementia, substance abuse or dependency, MRI-contraindications

Design outcomes

Primary

MeasureTime frame
3, 5 and 12month postpartum - Instructed mother-child-interaction: Face-to-Face-Still-Face-Paradigm -Maternal Bonding using questionnaires and interviews: Interview on postpartal bonding disorders (adapted from I. F. Brockington, Aucamp, & Fraser, 2006), Attachment Style Interview (Bifulco, Moran, Ball, & Bernazzani, 2002), Postpartum Bonding Questionnaire (PBQ-R; Reck et al., 2006), Parental Self Confidence Scale (LMSCS; Lips & Bloom, 1993), Infant Behavior Questionnaire (IBQ; Pauli-Pott, Mertesacker, & Beckmann, 2003)

Secondary

MeasureTime frame
3, 5 and 12 month postpartum: - Neuronale activity of the reward system (in response to stimuli of the own infant) - Stressreagibility (Heartreate and Cortisol in Saliva) - Methylation of the Oxytocin(-receptor-)gene

Countries

Germany

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 21, 2026