healthy subjects
Conditions
Interventions
Group 1: hyperinsulinemic-hypoglycemic clamp upon lactate infusion (sodium lactate i.v. 0.4 mol / l, 500 ml, pharmacy UKSH)
measurement of cerebral high-energy phosphates (ATP, PCr) by 31P-magnetic re
Sponsors
Sektion für Psychoneurobiologie
Eligibility
Sex/Gender
Male
Age
20 Years to 30 Years
Inclusion criteria
Inclusion criteria: normal weight, 20-30 years
Exclusion criteria
Exclusion criteria: diabetes mellitus, overweight (BMI > 26 kg/m²), chronic or acute illness, alcohol or drug abuse, smoking, competitive physical exercise, exceptional physical or mental stress, current medication of any kind
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| measurement of cerebral high-energy phosphates (adenosine triphosphate (ATP), phosphocreatine (PCr), inorganic phosphate (Pi)) by 31P-magnetic resonance spectroskopy (3.0 Tesla MR scanner) on six time points of measurement (Baseline, 15 minutes after start of lactate or placebo infusion, 3 measurements during hypoglycemia (every 20 minutes), 1 measurement after hypoglycemia) | — |
Secondary
| Measure | Time frame |
|---|---|
| counterregulatory hormones (ACTH, cortisol, epinephrine, norepinephrine) by analyses of blood samples on 10 time points of measurement (Baseline, after 60 minutes, 15 minutes after start of lactate or placebo infusion, 6 blood samples during hypoglycemia (every 10 minutes), 1 blood sample after hypoglycemia) | — |
Countries
Germany
Contacts
Public ContactKai Duysen
Sektion für PsychoneurobiologieCenter of Brain, Behavior and MetabolismUniversität zu Lübeck
Outcome results
None listed