Physical inactivity
Conditions
Interventions
Group 1: Sports intervention: Includes the independent performance of a standardized fitness circle in cooperating fitness centers, twice a week for 12 weeks.
Group 2: Sports and nutritional intervent
Sponsors
Institut für Lebensmittelwissenschaft und Humanernährung
Eligibility
Sex/Gender
All
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: - consent men and women - 50 - 70 years - so far physically inactive people who have not carried out specific sports activities outside of their daily activities for at least 2 years - sports capability - willingness to independently perform a training program for 12 weeks - willingness to implement given dietary recommendations in everyday life - willingness to take a multivitamin mineral preperation daily for 12 weeks - willingness to be assigned to the waiting control group and to receive the intervention after a waiting period of 12 weeks - stable weight since min. half a year (± 5 kg) - omnivorous diet
Exclusion criteria
Exclusion criteria: - severe chronic diseases (cancer, type 1 diabetes, etc.), manifest cardiovascular diseases, renal insufficiency, liver disease - chronic diseases of the gastrointestinal tract (e.g., ulcerative colitis, Crohn's disease, pancreatic insufficiency) - blood coagulation disorders - known immunological disorders (e.g., autoimmune diseases) - regular intake of laxatives - permanent use of immunosuppressive drugs (cortisone, anti-inflammatory drugs, non-steroidal anti-inflammatory drugs, etc.) - drug, alcohol and medication abuse - non-consenting subjects - simultaneous participation in another clinical study or participation within the past 30 days - ingestion of mineral and / or vitamin supplements, unless discontinued 6-8 weeks prior to study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determination of the CD4 / CD8 ratio of T-cells in venous blood at the beginning and at the end of the twelve-week intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| At the beginning and end of the intervention, the following parameters will be determined from venous blood: - i.a. immunological parameters, e.g. number of regulatory T-cells, T-cell apoptosis and activation markers (Annexin V and CD69) - i.a. biochemical parameters (e.g., parameters of iron metabolism, vitamin B12 (cobalamin)), - i.a. Health status survey (e.g., SF36) - i.a. Survey of diet and exercise behavior (e.g., FFQ, Freiburger Fragebogen questionnaire on physical activity) - anthropometric data | — |
Countries
Germany
Contacts
Public ContactPaulina Wasserfurth
Institut für Lebensmittelwissenschaft und Humanernährung
Outcome results
None listed