Investigation of the NOL (Nociception Level Index), ANI (Analgesia Nociception Index) and PPI (pupillary pain index) in Patients undergoing Orthopedic Surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00014304

Enrollment

Registered

2018-04-13

Start date

2019-01-01

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Z98.8

Interventions

Group 1: Patients undergoing orthopedic surgery with general or combined general/regional anesthesia, intraoperative NOL, ANI, PPI measurements, postoperative pain levels, opioid consumption (PACU)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with orthopedic surgery

Exclusion criteria

Exclusion criteria: Pregnancy chronic Opioid consumption

Design outcomes

Primary

Measure	Time frame
pain at PACU discharge, after 24h, after 48h relationship NOL (Nociception Level Index) / ANI (Analgesia Nociception Index) / PPI (pupillary pain index) and postoperative pain score	—

Secondary

Measure	Time frame
cumulative postoperative Opioid consumption	—

Countries

Germany

Contacts

Public ContactMarcus Thudium

Universitätsklinikum Bonn

marcus.thudium@ukbonn.de0228 287 15109

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 14, 2026