Relevance of DNIC (diffuse noxious inhibitory Control) for pain and hyperalgesia following an incision in healthy volunteers.

Relevance of DNIC (diffuse noxious inhibitory Control) for pain and hyperalgesia following an incision in healthy volunteers. - Incision CPM Study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00014291

Enrollment

Registered

2018-03-16

Start date

2010-05-10

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ENDOGENESCHMERZHEMMUNGUNDSENSITISIERUNGDIEZUAKUTEUNDCHRONSICHESCHMERZENFHRENKNNEN

Interventions

Group 1: In healthy male volunteers the CPM Paradigma (conditioned pain Modulation, formerly called DNIC - diffuse noxious inhibitory control) is evaluated on day one, using a contact heat stimulus ap

Eligibility

Sex/Gender

Male

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: healthy, male volunteers

Exclusion criteria

Exclusion criteria: Patients under 18 years of age, intake of analgesics or psychopharmaca, chronic pain condition, neurological condition, diabetes mellitus, hypertension

Design outcomes

Primary

Measure	Time frame
Difference in spontaneous pain after incision (evaluated with numeric rating scale 0-100 directly after incision) by comparing incisional pain with parallel activation of conditioned pain modulation (contralateral Hand in a noxious cold water bath during incision) and incisional pain without parallel activation of conditioned pain modulation (contralateral hand in a non-noxious lukewarm water bath during incision).	—

Measure

Time frame

Difference in spontaneous pain after incision (evaluated with numeric rating scale 0-100 directly after incision) by comparing incisional pain with parallel activation of conditioned pain modulation (contralateral Hand in a noxious cold water bath during incision) and incisional pain without parallel activation of conditioned pain modulation (contralateral hand in a non-noxious lukewarm water bath during incision).

—

Secondary

Measure	Time frame
Correlation between Conditioned Pain Modulation and thermal and mechanical thresholds and mechanical pain sensitivity before and 1, 3, 9 and 27 hours after induction of the experimental incision; Differences between incison during CPM and without CPM regarding the above mentioned parameters before and 1, 3, 9 and 27 hours after induction of the experimental incision	—

Countries

Germany

Contacts

Public ContactEsther Pogatzki-Zahn

Universitätsklinik Münster, Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie

pogatzki@anit.uni-muenster.de0251 8347261

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026