Tri-model system of [18F]FDG-PET, fMRT and HD-EEG to study state networks

Tri-model system of [18F]FDG-PET, fMRT and HD-EEG to study state networks - GK-PET/MR Tü-015

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00014276

Enrollment

Registered

2018-03-21

Start date

2019-04-24

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G40

Interventions

Group 1: Patients with epilepsy (n=20): Simultaneous [18F]FDG-PET, fMRT and HD-EEG (with/without finger-tapping for resting-stage and task-stage brain data akquisition). The data will be analysed and

Eligibility

Sex/Gender

All

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 20 male or female patients with epilepsy having a clinical indicated [18F]FDG-PET examination, and 20 age- and gender-matched healthy volunteers. For both groups: - non-smoker, - age =18 years, - BMI 20-35, - written informed consent.

Exclusion criteria

Exclusion criteria: - possible cardiovascular diesease - moderate to severe intellectual debility - physical or mental dependence, or other psychiatric diseases - repeated cerebral ischemia, repeated craniocerebral trauma, or rather encephalitis in anamnesis - positive familiy-anamnesis bearing neurodegenerative diseases - surgery during last 3 month - allergy - contra-indications for MRT - underage person or limited contractual capability - parallel participation in other clinical studies - job-related or other radiation exposure >15mSv/a - precnancy or breast-feeding women

Design outcomes

Primary

Measure	Time frame
The primary goal of the study is to gain more insight in complex brain networks using simultaneous [18F]FDG-PET/MR in combination with fMRI, and EEG. Network-data (resting-stage as well as task-stage) from patients with epilepsy will be acquired and subsequently compared to the data of healthy volunteers (age- and gender-matched).	—

Secondary

Measure	Time frame
Do [18F]FDG, fMRI, and EEG show convergent results for physiological, task-related network-activation? Which one and are this effects quantifiable? Do [18F]FDG, fMRI, and EEG show convergent results for phathological network-dysfunction in epilepsy? Are this results useful for the development of new therapy approaches?	—

Countries

Germany

Contacts

Public ContactNiels Focke

Universitätsklinikum Tübingen, Neurologische Epileptologie

niels.focke@med.uni-tuebingen.de07071-29 80466

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026