Can oral probiotics contribute to a well-balanced oral flora in orthodontic patients with brackets ? A Comparison of Lactobacillus Reuteri Prodentis and Streptococcus Salivarius M 18

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00014270

Enrollment

Registered

2018-06-06

Start date

2018-05-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Z29.9

Interventions

Group 1: Streptococcus Salivarius M18, the subjects take every evening after brushing their teeth a lozenge of the preparation PROBIO-DENT by SYXYL Group 2: Lactobacillus Reuteri Prodentis, the subjec

Eligibility

Sex/Gender

All

Age

10 Years to 21 Years

Inclusion criteria

Inclusion criteria: Multibracket appliance in a jaw for at least 3 months, No antibiotics for 3 months

Exclusion criteria

Exclusion criteria: No compliance expected

Design outcomes

Primary

Measure	Time frame
The influence of 2 different probiotics on a balanced oral flora can be significantly demonstrated. Measurement of parameters: - plaque index - gingival index - Determination of bacterial microflora before the professional tooth cleaning (T0) before the study (T1), after 6 weeks (T2) and after 6 weeks after stopping the daily intake (T3) Total duration of the investigation: 15 weeks	—

Secondary

Measure	Time frame
The absence of significant adverse events in probiotic therapy confirms the safety of this treatment. Check by questionnaire	—

Countries

Germany

Contacts

Public ContactSarah Bilir

Klinik für Kieferorthopädie

fi-br@kfo-zmk.uni-kiel.de0431 500 26301

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026