Selective depletion of C-reactive protein by means of therapeutic apheresis (CRP-apheresis) in acute pancreatitis

Selective depletion of C-reactive protein by means of therapeutic apheresis (CRP-apheresis) in acute pancreatitis - CAPRI1

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00014265

Enrollment

Registered

2018-03-12

Start date

2018-09-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K85.80

Interventions

Group 1: 20 patients with moderate or severe acute pancreatitis receive a maximum of 7 apheresis treatments at intervals of 24±12 hours.

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: • Acute pancreatitis according to the S3 Guideline Pancreatitis of the German Society for Gastroenterology, Digestive and Metabolic Diseases (DGVS) • Moderate or severe acute pancreatitis according to the Atlanta Classification of 2013 • CRP = 100 mg/l up to 24 hours after symptom onset or CRP = 150 mg/l if the onset of symptoms was more than 24 hours ago • Written informed consent

Exclusion criteria

Exclusion criteria: • Age < 18 or = 80 years • Positive harmless acute pancreatitis score (HAPS) • Therapy-refractory shock • Pregnancy or breastfeeding • Participation in other interventional trials

Design outcomes

Primary

Measure	Time frame
Safety and tolerability of CRP-apheresis in acute pancreatitis (incidence of expected and unexpected adverse effects of CRP-apheresis)	—

Secondary

Measure	Time frame
Course of the disease (Determination of laboratory parameters/diagnostic biomarkers/scores: • ALT, AST, gamma-GT, alkaline phosphatase, bilirubin, pro-calcitonin, CRP, leukocytes, hematocrit, creatinine, serum urea, eGFR, urine excretion • Modified CT severity index (MCTSI) • SAPS (Simplified Acute Physiology Score) • TISS (Therapeutic Intervention Scoring System) • BISAP score • Hospitalization • Presence and infection rate of pancreatic necrosis)	—

Measure

Time frame

Course of the disease (Determination of laboratory parameters/diagnostic biomarkers/scores: • ALT, AST, gamma-GT, alkaline phosphatase, bilirubin, pro-calcitonin, CRP, leukocytes, hematocrit, creatinine, serum urea, eGFR, urine excretion • Modified CT severity index (MCTSI) • SAPS (Simplified Acute Physiology Score) • TISS (Therapeutic Intervention Scoring System) • BISAP score • Hospitalization • Presence and infection rate of pancreatic necrosis)

—

Countries

Germany

Contacts

Public ContactWolfgang Ries

DIAKO Krankenhaus, Medizinische Klinik – Innere Medizin

rieswo@diako.de+49 461 812 1391

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026