CEST-imaging with or without application of glucose in healthy volunteers and patients with new intracerebral lesion (at clinical field intensity)

CEST-imaging with or without application of glucose in healthy volunteers and patients with new intracerebral lesion (at clinical field intensity) - CEST_MRI

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00014241

Enrollment

Registered

2018-03-06

Start date

2018-02-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C71

Interventions

Group 1: (gluco)CEST-MRT with or without injection of glucose (iv) in the context of a routine MRT diagnosis of the brain

Eligibility

Sex/Gender

All

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age: = 18 years, known lesion in the cerebrum (shown by image based diagnostic) (tumor of the brain, lymphoma or metastasis), written informed consent

Exclusion criteria

Exclusion criteria: General contra-indication for MRT, inability to lie quiescent for 60 min (due to pain, claustrophobia, etc.), insulin-dependent Diabetes mellitus or glucose-value >120 mg/dl , precnancy/ breast feeding women, limited contractual capability or underage person

Design outcomes

Primary

Measure	Time frame
Dynamic determination of glucose-uptake of tumors after injection of glucose (iv)	—

Secondary

Measure	Time frame
1. Correlation of glucoCEST contrast with conventional imaging (T1w, T2w, ADC, DCE-T1w), native CEST and PET-contrast (if available), 2. Correlation of glucoCEST-signals with survival and progression-free survival, 3. Comparison of glucoCEST-signals with amid-CEST (without glucose injection)	—

Countries

Germany

Contacts

Public ContactBenjamin Bender

Radiologische Klinik, Universitätsklinikum Tübingen, Abt. Neuroradiologie

benjamin.bender@med.uni-tuebingen.de07071-2985397

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026