Study of induction and maintenance of anaesthesia with different hypnotics

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00014237

Enrollment

180

Registered

2018-08-10

Start date

2002-07-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Electroencephalogram Induction of anaesthesia

Interventions

Group 1: Induction of anaesthesia with propofol Group 2: Induction of anaesthesia with thiopental Group 3: Induction of anaesthesia with methohexital Group 4: Induction of anaesthesia with etomidate

Eligibility

Sex/Gender

All

Age

20 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients who undergo gynecological, urological or general surgical operations with a duration of at least 30 minutes in general anesthesia with tracheal intubation and normocapnic ventilation.

Exclusion criteria

Exclusion criteria: Patients with known epilepsy or under antiepileptic medication, patients with a history of cranio-cerebral trauma, known oliguria/anuria, hypo- or hyperthyroidism, severe heart failure, severe acid-base, electrolyte, or haematological disorders.

Design outcomes

Primary

Measure	Time frame
Spectral composition of the EEG (electroencephalogram) during/after administration of propofol, thiopental, methohexital, or etomidate.	—

Secondary

Measure	Time frame
Occurrence of special EEG (electroencephalogram) patterns during/after administration of propofol, thiopental, methohexital, or etomidate.	—

Countries

Germany

Contacts

Public ContactBarbara Schultz,

Medizinische Hochschule Hannover, Klinik für Anästhesiologie und Intensivmedizin,

schultz.barbara@mh-hannover.de0511/532-0

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026