Interpreting non-coding variants underlying shared genetics (pleiotropy) between Type 2 Diabetes and Alzheimer's disease

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00014182

Enrollment

Registered

2018-03-08

Start date

2018-01-12

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy volunteers

Interventions

Group 1: The subjects appear fasted in the morning in the study center. There, approximately 50 ml of blood is removed. In addition, size and weight are determined according to SOPs. The blood will be

Eligibility

Sex/Gender

Male

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Healthy men between 18 and 40 years of age. BMI between 18,5 und 30 kg/m². Written informed consent.

Exclusion criteria

Exclusion criteria: Type 1 and 2 Diabetes. Smoking. Cardiovascular disease. Other serious disease (such as cancer). Antibiotic treatment in the last 6 months.

Design outcomes

Primary

Measure	Time frame
The primary expected outcomes are changes in activation and differentiation capacity of T cells after gene knock-down and genome editing.	—

Secondary

Measure	Time frame
The secondary outcomes are the effect of the manipulated T cells in adipose and brain tissue to confirm pleiotropy.	—

Countries

Germany

Contacts

Public ContactIsabel Sousa

TUM

isabel.sousa@tum.de08161712011

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026