Symptom-guided treatment influences brain plasticity - Neurofeedback-based training in patients with psychomotoric affective symptoms

Symptom-guided treatment influences brain plasticity - Neurofeedback-based training in patients with psychomotoric affective symptoms - APIC-PNF

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

DRKS

Registry ID

DRKS00014181

Enrollment

Registered

2018-03-07

Start date

2018-03-11

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F32 F33 F31.3 F34 F20 F21 F22 F23 F24 F25 F28 F29

Interventions

Group 1: Neurofeedback training in patients with depression according to the ICD-10 criteria: F32.x, F33.x, F31.3 or F34.x. Neurofeedback training: Participants will be trained in cognitive regulation

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria for all participants: - Age: 18 - 75 years, - good knowledge of German.

Exclusion criteria

Exclusion criteria: Exclusion criteria for all participants: - pregnancy or nursing period, - contraindications to MR examinations, such as magnetic metal implants, large-scale tattoos or claustrophobia, - Participants or patients that are not able to consent to the study

Design outcomes

Primary

Measure	Time frame
The effect of neurofeedback training on apathy (lack of motivation) in patients diagnosed with depression will be assessed using the self-reported Apathy Evaluation Scale (AES) questionnaire. The participants will fill out the AES on the first day of enrollment. Following this day, on two other days a neurofeedback training will be performed using fMRI. The two measurement days in the cross-over design will be separated by a week. After the final day of training, we will issue another AES questionnaire to the participant. Following this, there will be a follow up day, approximately four weeks after the second measurement. On the follow up day, we will again issue the AES. We will assess the effect our neurofeedback training paradigm had on the brain activity of the supplementary motor area (SMA) measured by fMRI. And how this change in SMA activity influences apathy in depressive patients.	—

Measure

Time frame

The effect of neurofeedback training on apathy (lack of motivation) in patients diagnosed with depression will be assessed using the self-reported Apathy Evaluation Scale (AES) questionnaire. The participants will fill out the AES on the first day of enrollment. Following this day, on two other days a neurofeedback training will be performed using fMRI. The two measurement days in the cross-over design will be separated by a week. After the final day of training, we will issue another AES questionnaire to the participant. Following this, there will be a follow up day, approximately four weeks after the second measurement. On the follow up day, we will again issue the AES. We will assess the effect our neurofeedback training paradigm had on the brain activity of the supplementary motor area (SMA) measured by fMRI. And how this change in SMA activity influences apathy in depressive patients.

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Secondary

Measure	Time frame
The effect of neurofeedback training on impulsivity in patients diagnosed with depression will be assessed using reaction times as measured by a Go-NoGo task. After the first day of enrollment, neurofeedback training will be performed using fMRI, on two more days. The two measurement days will be separated by a week. On each day there will be three neurofeedback training sessions during the measurement. Reaction times will be measured before the first session, then in between the next two sessions and also after the last session. The same will be repeated on the second measurement day. It will be assessed the effect of our neurofeedback training paradigm on the brain activity of the supplementary motor area (SMA), measured by fMRI. And how this change in SMA activity influences impulsivity in depressive patients.	—

Measure

Time frame

The effect of neurofeedback training on impulsivity in patients diagnosed with depression will be assessed using reaction times as measured by a Go-NoGo task. After the first day of enrollment, neurofeedback training will be performed using fMRI, on two more days. The two measurement days will be separated by a week. On each day there will be three neurofeedback training sessions during the measurement. Reaction times will be measured before the first session, then in between the next two sessions and also after the last session. The same will be repeated on the second measurement day. It will be assessed the effect of our neurofeedback training paradigm on the brain activity of the supplementary motor area (SMA), measured by fMRI. And how this change in SMA activity influences impulsivity in depressive patients.

—

Countries

Germany

Contacts

Public ContactKlaus Mathiak

Universitätsklinikum der RWTH Aachen

kmathiak@ukaachen.de0241 80 80523

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026