K75.8
Conditions
Interventions
Group 1: Lifestyle Intervention (guidance in physical activity and nutrition)
Group 2: meal replacement (with a commercially available soy-joghurt-honey preparation)
Sponsors
Universitätsklinikum FreiburgPräventive und Rehabilitative Sportmedizin
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: BMI between 30 - 40 kg/m² possible participation in sports program elevation of liver enzymes (ALT, AST or ggT)
Exclusion criteria
Exclusion criteria: - performance capacity < 75W for 2 minutes - absolute or relative contraindications to physical training according to the guidelines of the ACSM (American College of Sports Medicine) - insulin-dependent diabetes mellitus - chronic kidney diseasae - intake of appetite modifying medication - psychiatric disease with continued supervision of a physician - history of malignant disease within the last 5 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in hepatic lipid content (measured after 24 weeks with MRI) | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in body composition (after 24 weeks, measured by MRI) Change in fat mass (after 24 weeks, measured by BodPod) Changes in liver enzymes (after 24 weeks, measured by standard laboratory methods) Changes in hepatic lipid composition (after 24 weeks, measured by MRI-spectroscopy) Changes in adipokines (after 24 weeks, measured by ELISA) | — |
Countries
Germany
Contacts
Public ContactPeter Deibert
Universitätsklinikum
Outcome results
None listed