Biochemical response to a single bout of Whole Body Vibration

Biochemical response to a single bout of Whole Body Vibration - BEST OF Study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00014052

Enrollment

Registered

2018-02-16

Start date

2018-04-13

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy volunteers

Interventions

Group 1: Single bout of Whole Body Vibration up to the individual's max. capacity (30s-5min). After that 120min after cessation blood samples will be taken to measure changes in myokin levels.

Eligibility

Sex/Gender

Male

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: - Males, aged = 18 years, =40 years - Signed informed consent

Exclusion criteria

Exclusion criteria: - Acute Heart attack 6 months prior to participation - Unstable Angina Pectoris and history of exercise induced angina - Symptomatic cardiac arrhythmias and/or compromised hemody-namics - Symptomatic severe aortic stenosis - Reported dilatation of arteries (aneurysms) at any site - Reported heart valve problems (stenosis or insufficiency) - Any symptomatic or reported stenosis of peripheral arteries - Congestive heart failure - Acute pulmonary embolism 6 months prior to participation - Acute myocarditis / pericarditis - Acute Aortic dissection - Limb Surgery 6 weeks prior to participation - Acute fracture 12 weeks prior to participation - Acute infection - Thromboembolism 3 months prior to participation - Severe bronchial Asthma - Uncontrolled Diabetes Mellitus - Severe Vertigo - Uncontrolled arterial hypertension (BP >200 mmHg syst., >110 mmHg diast.) - Hypertrophic cardiomyopathy or any other kind of outflow tract ob-struction - Higher degree AV-Block - Acute hernia disc prolapse (< 3 months) - Epilepsy - Kidney stones - Gallstones - Acute hernia - Rheumatoid Arthritis - Any medical condition that might in the investigators opinion pose the subject at increased risk of experiencing a deterioration of his/her health status.

Design outcomes

Primary

Measure	Time frame
Change in Follistatin-like-3 levels in peripheral blood at 120 min after a single bout of WBV	—

Secondary

Measure	Time frame
Intra-individual changes at 120min after a single bout of Whole Body Vibration of Follistatin, Klotho, Myostatin, CTGF, CYR61 (CCN1 and 2) and correlations with parameters of musculoskeletal tests (Grip strength, SPPB, 6MW, BIA, Jumping Height)	—

Countries

Germany

Contacts

Public ContactFranca Genest

Lehrstuhl für Orthopädie, König Ludwig Haus

f-genest.klh@uni-wuerzburg.de0931 803 3144

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026