Comparison of bioactive glass S53P4 as bone graft substitute and autologous bone graft in the treatment of chronic osteomyelitis and infected non-unions – a comparative retrospective study

Comparison of bioactive glass S53P4 as bone graft substitute and autologous bone graft in the treatment of chronic osteomyelitis and infected non-unions – a comparative retrospective study - Bioactive glass versus autologous bone graft in osteomyelitis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00014049

Enrollment

100

Registered

2018-02-26

Start date

2018-03-02

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

M86.6

Interventions

Group 1: Retrospective analysis of bony defect filling with bioactive glass S53P4 in patients with chronic osteomyelitis and/ or infected non-unions between 07/2013 and 01/2017 Group 2: Retrospective

Eligibility

Sex/Gender

All

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Chronic osteomyelitis and/ or infected non-union - Filling of the bony defect with either autologous bone graft or bioactive glass S53P4 - Follow-up at a minimum of 12 months

Exclusion criteria

Exclusion criteria: - Aseptic non-union - Follow-up < 12 months

Design outcomes

Primary

Measure	Time frame
Permanent control of infection during follow-up (date of filling the defect – max. 01/2018) All findings of the consultation hours – independent of this study – are evaluated	—

Secondary

Measure	Time frame
- Bony fusion, respectively incorporation of the bioactive glass - Full weight bearing - Complications due to bioactive glass, respectively the extraction of autologous bone graft - Complications All findings of the consultation hours – independent of this study – are evaluated	—

Countries

Germany

Contacts

Public ContactEva Steinhausen

BG Klinikum Duisburg

evasimone.steinhausen@bg-klinikum-duisburg.de+49 203 7688 0

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 14, 2026