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Neuropsychological follow-up of patients of the study: "A randomised, controlled, open-label study to confirm the efficacy and safety of sedation with isoflurane in invasively ventilated ICU patients" (Isoconda)

Neuropsychological follow-up of patients of the study: "A randomised, controlled, open-label study to confirm the efficacy and safety of sedation with isoflurane in invasively ventilated ICU patients" (Isoconda)

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
DRKS
Registry ID
DRKS00014030
Enrollment
100
Registered
2018-11-05
Start date
2017-12-20
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

PICS (Post-intensive Care Syndrome) F05.9 F43.9 F32.9 Z74

Interventions

Group 1: Isoflurane sedation, dosing with targeted RASS (Richemont Agitation and Sedation Score) for at least 48h (Isoconda study) and subsequent assessment of neuropsychological outcome 1, 3, and 12

Sponsors

Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Participation in the Isoconda study

Exclusion criteria

Exclusion criteria: Aphasia, insufficient spoken and written language skills in German, no consent

Design outcomes

Primary

MeasureTime frame
Extent of delusional memories using the Intensive Care Unit (ICU) memory tool 4 weeks, 3 months, and 12 months after discharge from the intensive care unit—

Secondary

MeasureTime frame
1. Incidence of the occurrence of a delirium 24 hours after extubation using the CAM-ICU (Confusion Assessment Method for the Intensive Care Unit) 2. Frequency of symptoms of posttraumatic stress syndrome based on PTSS-14 (Post-Traumatic Stress Syndrome 14) 3. Health-related quality of life based on the SF-36 (Short Form 36)—

Countries

Germany

Contacts

Public ContactAlexandra Donie

Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie

Alexandra.Donie@uks.eu+49(0)6841-16-22485

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026