G12 E74
Conditions
Interventions
Group 1: At night time 15 patients with an ongoing nocturnal NIV (Non-invasive ventilation) therapy for hypoventilation due to a NMD (Numerous neuromuscular disorders) will be attached to a full cardi
Sponsors
Department für Neurologie - Klinik für Schlafmedizin und neuromuskuläre Erkrankungen Universitätsklinikum Münster
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: a. Age > 18 years (no age limit) b. able to consent c. proven NMD d. ongoing nocturnal NIV therapy with a nasal mask for hypoventilation due to a NMD e. good tolerance of and adherence to the ongoing NIV therapy with minimal nasal mask-related problems/discomfort f. no vital indication for NIV use at night
Exclusion criteria
Exclusion criteria: - Body Mass Index (BMI) > 35 - Heart failure with left ventricular ejection fraction <50% - Chronic obstructive pulmonary disease, emphysema - Severe psychiatric disease including dementia - Thoracic wall disease - Cardiac pacemaker
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Transcutaneous CO2 [mmHG] -> measured at night and under the above mentioned interventions | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate [bpm], systolic blood pressure [mmHG], diastolic blood pressure [mmHG], stroke volume index [L/min/m²], high frequency component of diastolic blood pressure variability[%], low frequency component of heart rate variability [%], respiratory rate [/min], tidal volume [ml], minute ventilation [L/min], oxygen saturation [%], high frequency component of heart rate variability [%], low frequency component of diastolic blood pressure variability [%] -> measured at night and under the above mentioned interventions | — |
Countries
Germany
Contacts
Public ContactMatthias Boentert
Department für Neurologie- Klinik für Schlafmedizin und neuromuskuläre Erkrankungen Universitätsklinikum Münster
Outcome results
None listed