primary breasttumor C50
Conditions
Interventions
Group 1: Pre- or postmenopausal women with a primary breast tumor, PET/MRT examination pre-surgery.
Sponsors
Universitätsklinikum Tübingen, Radiologiesche Klinik, Interv. u. Diagnostische Radiologie
Eligibility
Sex/Gender
Female
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: women, age =18 years, proven primary breast carcinoma (by punch biopsy, =14G) (subtypes luminal A, B, and HER-"/neu-pos. basal-like tumors) tumor size =10 mm, clinical indication for primary surgery, contraception, informed consent for clinical study, informed consent for useage of biomaterial
Exclusion criteria
Exclusion criteria: clinical indication for neo-adjuvant therapy, precnancy/breast feeding women, contra-indication for MRT such as metallic implants, pacemaker etc., clip-marking of breast tumor, contra-indication for MR-contrast agent Gadolinium, claustrophobia, high sensitivity to temperatur sensitivity, high sensitivity to noise, limited contractual capability, exclusion criteria due to StrlSchV such as job-related radiation exposure >15mSv/a
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Feasibiliy: Recovery of complete datasets composed of PET/MR-image data and corresponding morphologic data (histopathological). Possibility to define different intra-tumoral cluster by imaging data. | — |
Secondary
| Measure | Time frame |
|---|---|
| Development and clinical use of machine-learning approaches for texture analysis of breast tumors, subtyping breast tumors by multiparametric imaging data sets regarding prognosis and therapy response, voxel-based analysis of PET/MR data sets and correlation with corresponding genom-, proteom- and metabolom-data sets | — |
Countries
Germany
Contacts
Public ContactMarkus Hahn
Universitätsklinikum Tübingen, Frauenklinik
Outcome results
None listed