Renal biomarkers in hantavirus infection

Renal biomarkers in hantavirus infection - ReBIHI (Renal biomarkers in hantavirus infection)

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00013884

Enrollment

300

Registered

2019-01-22

Start date

2019-01-27

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

N17.9 A98.5

Interventions

Group 1: Patients with proven or suspected hantavirus infection and age = 18 are enrolled: - Biomarker-Measurement in blood and urine samples (0h/d0 [t0], 24h/d1 [t1], 48h/d2 [t2], and every other day

Eligibility

Sex/Gender

All

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Being able to give consent - Written consent form of study participants - Suspicion of Hantavirus infection or proven Hantavirus infection - Women and men at the age of 18-99 years

Exclusion criteria

Exclusion criteria: - Non-fulfillment of inclusion criteria - Refusal of participation

Design outcomes

Primary

Measure	Time frame
- Evaluation of renal damage biomarkers concerning their potential to predict a severe disease course during Hantavirus-associated acute kidney injury (AKI). (Measurement 0h/d0 [t0], 24h/d1 [t1], 48h/d2 [t2] and every other day until discharge) - Differentiation of the biomarkers and evaluation of their correlation with laboratory values and cellular substructures. (Measurement 0h/d0 [t0], 24h/d1 [t1], 48h/d2 [t2] and every other day until discharge)	—

Measure

Time frame

- Evaluation of renal damage biomarkers concerning their potential to predict a severe disease course during Hantavirus-associated acute kidney injury (AKI). (Measurement 0h/d0 [t0], 24h/d1 [t1], 48h/d2 [t2] and every other day until discharge) - Differentiation of the biomarkers and evaluation of their correlation with laboratory values and cellular substructures. (Measurement 0h/d0 [t0], 24h/d1 [t1], 48h/d2 [t2] and every other day until discharge)

—

Secondary

Measure	Time frame
- Comparison of biomarkers with already established, intrinsic markers of renal function and evaluation of their correlation with length of inpatient stay and need for renal replacement therapy. (Measurement 0h/d0 [t0], 24h/d1 [t1], 48h/d2 [t2] and every other day until discharge) - Analysis of potential (clinical) risk factors predisposing for a Hantavirus infection and severe disease courses. - Analysis of different RNA-/DNA-expression patterns/methylation patterns in urine and blood and their correlation with AKI course, multifactorial AKI and hanta virus pathogenesis. (Measurement 0h/d0 [t0], 24h/d1 [t1], 48h/d2 [t2] and every other day until discharge)	—

Measure

Time frame

- Comparison of biomarkers with already established, intrinsic markers of renal function and evaluation of their correlation with length of inpatient stay and need for renal replacement therapy. (Measurement 0h/d0 [t0], 24h/d1 [t1], 48h/d2 [t2] and every other day until discharge) - Analysis of potential (clinical) risk factors predisposing for a Hantavirus infection and severe disease courses. - Analysis of different RNA-/DNA-expression patterns/methylation patterns in urine and blood and their correlation with AKI course, multifactorial AKI and hanta virus pathogenesis. (Measurement 0h/d0 [t0], 24h/d1 [t1], 48h/d2 [t2] and every other day until discharge)

—

Countries

Germany

Contacts

Public ContactChristian Nusshag

Nierenzentrum Heidelberg, Universitätsklinikum Heidelberg

Christian.Nusshag@med.uni-heidelberg.de06221/5634952

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026