Analysis of initial intra- and extracellular activation factors in multiple trauma patients in the early posttraumatic period

Analysis of initial intra- and extracellular activation factors in multiple trauma patients in the early posttraumatic period - -

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00013666

Enrollment

150

Registered

2018-02-27

Start date

2001-03-19

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

T07 R65

Interventions

Group 1: Patients of full age suffering from blunt multiple injuries with ISS=16 points who were admitted to our emergency department within 90 minutes after trauma were included. Blood samples were d

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Multiple trauma; ISS = 16 points; 1. Blood drawn within 90 minutes after trauma; Blunt trauma; > 18 years

Exclusion criteria

Exclusion criteria: ISS < 16 points; chronic disease; terminal disease; autoimmune disease; immune suppression; pregnancy; death within 24h after trauma

Design outcomes

Primary

Measure	Time frame
Evaluation of individual response pattern defined by this leukocyte subset following major trauma 1. Evaluation of neutrophil gene expression profiles in multiple trauma patients in the early posttraumatic period (within the first 72 hours) 2. Correlation of neutrophil gene expression patterns and distinct clinical outcome parameter 3. Evaluation of serum protein concentration dynamic following multiple trauma 5. Correlation of serum protein concentration and distinct clinical outcome parameter	—

Measure

Time frame

Evaluation of individual response pattern defined by this leukocyte subset following major trauma 1. Evaluation of neutrophil gene expression profiles in multiple trauma patients in the early posttraumatic period (within the first 72 hours) 2. Correlation of neutrophil gene expression patterns and distinct clinical outcome parameter 3. Evaluation of serum protein concentration dynamic following multiple trauma 5. Correlation of serum protein concentration and distinct clinical outcome parameter

—

Countries

Germany

Contacts

Public ContactMareen Braunstein

Klinik für Allgemeine, Unfall- und Wiederherstellungschirurgie der LMU München

Mareen.Braunstein@med.uni-muenchen.de089-4400-52511

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026