Long-Term Early Development Research: serum-biomarkers for cerebral damage as predictors for neurocognitive deficits and for the course of neurocognitive development of children after cardiopulmonary resuscitation

Long-Term Early Development Research: serum-biomarkers for cerebral damage as predictors for neurocognitive deficits and for the course of neurocognitive development of children after cardiopulmonary resuscitation - LEADER-CPR

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00013639

Enrollment

100

Registered

2017-12-21

Start date

2017-12-21

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Q21.0 Q21.3 Q24.9 Q20.3 T98.3 I46.0 T88.8 G93.1 R62.9

Interventions

Group 1: Children with heart disease who underwent CPR (Cardiopulmonary resuscitation) and who were hospitalized at the German Heart Center Berlin. These children will be assessed 6, 12, 24 and 36 mon

Eligibility

Sex/Gender

All

Age

0 Months to 16 Years

Inclusion criteria

Inclusion criteria: • CPR =5min • Hospitalization at DHZB after CPR • Consent of parents/legal guardian • German mother tongue of at least one parent

Exclusion criteria

Exclusion criteria: • No consent of parents/legal guardian • Pre-existing, not differentially diagnosed neurocognitive deficits • Known or suspected retardation syndromes • Known drug and/or alcohol abuse of the mother during pregnancy.

Design outcomes

Primary

Measure	Time frame
The motoric, cognitive and language development as measured with the Bayley III Scale/ WPPSI-III/ WISC-IV at 6, 12, 24, 36 months after CPR.	—

Secondary

Measure	Time frame
• Mortality • Neurological status at discharge from hospital as measured with the PCPC (Pediatric Cerebral Performance Category Scale) and PSOM-SNE (Pediatric Stroke Outcome Measure Short Neuro Exam) • Morbidity and Organ dysfunction (renal failure, liver damage, heart failure, nutritional disorder)	—

Countries

Germany

Contacts

Public ContactHannah Ferentzi

Deutsches Herzzentrum Berlin

hannah.ferentzi@dhzc-charite.de03045932847

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026