Explorative study of neutrophil extracellular traps formation and their influence on coagulation in human sepsis and systemic inflammation

Explorative study of neutrophil extracellular traps formation and their influence on coagulation in human sepsis and systemic inflammation - SEPNETs

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00013584

Enrollment

Registered

2018-07-11

Start date

2018-09-17

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

A41

Interventions

Group 1: Methodik per patient 4 blood collection time points

per time point quantification of capillary perfusion (O2C) and coagulation (global parameters, thrombelastography), NET-quantification (flowzytometry), measurement of ROS-activity (ESR) und quantifica

2. SIRS following major surgery

3. SIRS following cardiopulmonary bypass

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: age>18 years signed informed consent

Exclusion criteria

Exclusion criteria: age <18 years, pregnancy, severe valvular heart disease (III°), active autoimmune disorders, active solid or hematogenic malignancies, disorders with need of immunosuppressive therapy

Design outcomes

Primary

Measure	Time frame
NETs in peripheral blood (quantified with flow cytometry)	—

Secondary

Measure	Time frame
1. Severity of coagulopathy (thrombelastography) 2. Amount of free circulating mitochondrial DNA (qPCR) 3. mount of free circulating and mitochondrial ROS (ESR) 4. Severity of peripheral perfusion problems (O2C)	—

Countries

Germany

Contacts

Public ContactMichael Sander

Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie

emmanuel.schneck@chiru.med.uni-giessen.de0049064198544401

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 11, 2026