Stress response to anesthesia and surgery during elective caesarean section
Conditions
Interventions
Group 1: Utiva (remifentanil), 1 µg/kg iv bolus followed by infusion 0.15 µg/kg/min
Group 2: Utiva (remifentanil), 1 µg/kg iv bolus before the induction to anesthesia
Group 3: patients who are not gi
Sponsors
Clinic of Gynaecology and Obstetrics Clinic of Anaesthesiology University Clinical Center Nis
Eligibility
Sex/Gender
Female
Age
19 Years to 35 Years
Inclusion criteria
Inclusion criteria: Patients ASA I and II status, scheduled for elective caesarean section in general anesthesia who have given written informed consent All patients refuse or have absolute/relative medical contraindications to regional anesthesia.
Exclusion criteria
Exclusion criteria: Exclusion criteria are: known cardiac, respiratory, neurologic, renal, endocrine, psychiatric disorders, history of drug or alcohol abuse, morbid obesity, preeclampsia, predicted difficult airway management, active labor, known fetal congenital abnormalities or signs of fetal compromise.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Our main goal is to compare the changes of maternal blood pressure, heart rate values measured after endotracheal intubation, skin incision, peritoneal incision and delivery during caesarean cestion between groups. We also compare neonatal outcome between groups (Apgar scores at 1st and 5th minute, HR, oxygen saturation, the need for resuscitative measures and umbilical venous and arterial blood gas values). | — |
Secondary
| Measure | Time frame |
|---|---|
| Our second goal is to measure and compare between groups: - the amount of thiopentone needed to achieve adequate dept of anesthesia (BIS = Bispectral Index between 40 and 60) at the induction, - the end-tidal sevoflurane concentration needed to keep adequate dept of anesthesia during induction to delivery (I-D) period and during the period from the delivery until the end of the operation, - the amount of remifentanil needed to provide adequate analgesia and hemodynamic stability during the period from the delivery until the end of operation, - the intubating conditions, classified as excellent, good or poor, based on following variables: the degree of jaw relaxation and of resistance to laryngoscope, vocal cords position and movement, limb movement or cough during tube insertion and cuff inflation - the duration of whole operation, I-D period, uterine incision to delivery (U-D) period, period from the end of remifentanil administration until delivery, intraoperative blood loss, total oxytocine consumption | — |
Countries
Serbia
Contacts
Public ContactMarija Kutlesic
Clinic of Gynaecology and Obstetrics University Clinical Centre Nis
Outcome results
None listed