F20
Conditions
Interventions
Group 1: Schizophrenia patients undergo an fMRI (Functional Magnetic Resonance Imaging) examination with concurrent oculographic measurement. In addition, a neuropsychological test battery is conducte
Sponsors
Rheinische Friedrich-Wilhelms-Universität Bonn
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: For participants with high and low levels of schizotypy: Age: 18-40 years; Language: sufficient knowledge of German; a score above or below a certain threshold in a questionnaire for measuring schizotypy (Oxford-Liverpool Inventory of Feelings and Experiences) For schizophrenia patients: Age: 18-40 years; Language: sufficient knowledge of German; schizophrenia diagnosis (ICD-10 and SCID criteria); duration of illness < 3 years
Exclusion criteria
Exclusion criteria: For participants with high and low levels of schizotypy: alcohol dependency / abuse; drug dependency / abuse; current diagnosis of a psychiatric disorder assessed with the Mini International Neuropsychiatric Interview o major depression o dysthymia o manic episode o panic disorder o agoraphobia o social phobia o obsessive-compulsive disorder o posttraumatic stress disorder o psychotic disorder o anorexia nervosa o bulimia nervosa o generalized anxiety disorder first degree relative with a diagnosed psychotic disorder; current or past somatic disorder potentially affecting the structure or functioning of the brain; current or past neurological disorder or brain injury; current or past head trauma with a loss of consciousness > 5 minutes;; current regular consumption of any medication (other than contraceptive pill, vitamins or thyroid medication; occasional medication like aspirin is acceptable, as long as it is not taken during the examination day); MRI exclusion criteria (claustrophobia, pregnancy, unremovable metal parts in the body) For schizophrenia patients: alcohol dependency / abuse; drug dependency / abuse; bipolar disorder; unipolar depression with psychotic symptoms; organic acute and chronic syndromes such as dementia or delirium, current or past somatic disorder potentially affecting the structure or functioning of the brain; current or past neurological disorder or brain injury; current or past head trauma with a loss of consciousness > 5 minutes; current regular consumption of any medication (other than antipsychotic medication, contraceptive pill, vitamins or thyroid medication; occasional medication like aspirin is acceptable, as long as it is not taken during the examination day); MRI exclusion criteria (claustrophobia, pregnancy, unremovable metal parts in the body)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. neuropsychological test battery, e.g., Continuous Performance Test, Auditory Verbal Learning Test, Figure of Rey etc. [dependent variable (DV) = performance] 2. Measurement of eye movements (DV = performance) with concurrent functional magnetic resonance imaging (DV = BOLD signal); Measurements 1. and 2. take place on two different days (not more than 4 weeks apart) or on the same day. | — |
Secondary
| Measure | Time frame |
|---|---|
| questionnaires for the assessment of relevant environmental influences | — |
Countries
Germany
Contacts
Public ContactEliana Faiola
Universität Bonn, Institut für Psychologie
Outcome results
None listed