Invasive mechanical ventilation
Conditions
Interventions
Group 1: Ventilation with "Adaptive Ventilation Mode" (AVM) for 1 hour
Group 2: Ventilation with "Adaptive Ventilation Mode 2" (AVM2) for 1 hour
Sponsors
Universitätsklinikum Schleswig-Holstein
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Patients on invasive mechanical Ventilation on intensive care units - arterial line for invasive blood pressure measurement present - Age > 18 years - written informed consent
Exclusion criteria
Exclusion criteria: - expiratory time constant > 1.5 s - PaO2/FiO2 Ratio 70 mmHg despite optimization of Ventilator Settings by treating ICU physician - acute severe hemodynamic instability (mean arterial pressure 150/min OR heart rate < 40/min) - high frequency oscillatory Ventilation - spontaneous breathing activity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tidal volume in ml per kg predicted body weight after one hour of mechanical ventilation with the respective mode (AVM or AVM2) | — |
Secondary
| Measure | Time frame |
|---|---|
| - Driving pressure (Difference between airway plateau pressure and end-expiratory airway pressure, cmH2O) - power of breathing (J/min) - arterial partial pressure of oxygen (mmHg) - arterial partial pressure of carbon dioxide (mmHg) - pH - alveolar Minute Ventilation (l/min, calculated as (tidal volume - Serial dead space volume) * respiratory rate) - mean airway pressure (cmH2O) - mean arterial pressure (mmHg) - heart rate (1/min, ECG) | — |
Countries
Germany
Contacts
Public ContactTobias Becher
Universitätsklinikum Schleswig-Holstein Campus Kiel, Klinik für Anästhesiologie und Operative Intensivmedizin
Outcome results
None listed