Non contrast-enhanced short-time MRI and conventional CT: Comparison of diagnostic parameters in patients with acute neurological symptoms

Non contrast-enhanced short-time MRI and conventional CT: Comparison of diagnostic parameters in patients with acute neurological symptoms - Ultrafast Brain MRI in Acute Neurological Emergencies: the FAMILIES trial (LMU-RAD00055)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00013356

Enrollment

150

Registered

2017-12-01

Start date

2017-12-05

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I67.88 I63.0 R58

Interventions

Group 1: This study begins with the selection of suitable patients in accordance to our specified inclusion and exclusion criteria which are based upon consultations with our colleagues in the interdi

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - patients of the emergency department of the Ludwig-Maximilians-University (LMU) Munich-Großhadern (minimum age 18 years) - suspected intracranial pathologies (hemorrhage, ischemia, tumor, signs of inflammation, edema, increased intracranial pressure (ICP)) - insufficient explanation of symptoms after examination using the cranial computed tomography

Exclusion criteria

Exclusion criteria: - patients with MRI-incompatible intracorporeal material (e.g. pacemaker, bladder pacemaker, nerve stimulators) - lacking capability of giving consent - minors - claustrophobia - unstable general condition - pregnancy - sufficient explanation of symptoms by the cranial computed tomography

Design outcomes

Primary

Measure	Time frame
The primary outcome of this study will be accomplished after the examination results have been assessed by a specialist and the sensitivities and specificities of the CT examination, accelerated MRI protocol and standard MRI protocol have been determined. The sensitivities and specificities of the CT examination, accelerated MRI protocol and standard MRI protocol (reference standard) will be compared and evaluated. We assume that the results of the standard and accelerated protocols will be virtually identical and the accelerated protocol will prove to be superior to CT.	—

Measure

Time frame

The primary outcome of this study will be accomplished after the examination results have been assessed by a specialist and the sensitivities and specificities of the CT examination, accelerated MRI protocol and standard MRI protocol have been determined. The sensitivities and specificities of the CT examination, accelerated MRI protocol and standard MRI protocol (reference standard) will be compared and evaluated. We assume that the results of the standard and accelerated protocols will be virtually identical and the accelerated protocol will prove to be superior to CT.

—

Secondary

Measure	Time frame
Two blinded, independent readers will analyze all pseudonymised records. All pathologies/observations detected in the accelerated and standard MRI protocols will be recorded. Additionally, examination quality of the accelerated and standard MRI protocols will be assessed analogous to Prakkamukal et al. (J Neuroimaging 2016;26:503-510) (1 - nondiagnostic, 2 - poor image quality and substantial artifacts, 3 - satisfactory, 4 - good image quality and minor artifacts, 5 - excellent image quality without artifacts). Gray-white matter differentiation will also be assessed analogous to Prakkamukal et al. (0 – no visible gray-white matter differentiation, 1 - unclear but recognizable borders, 2 - clear differentiation).	—

Measure

Time frame

Two blinded, independent readers will analyze all pseudonymised records. All pathologies/observations detected in the accelerated and standard MRI protocols will be recorded. Additionally, examination quality of the accelerated and standard MRI protocols will be assessed analogous to Prakkamukal et al. (J Neuroimaging 2016;26:503-510) (1 - nondiagnostic, 2 - poor image quality and substantial artifacts, 3 - satisfactory, 4 - good image quality and minor artifacts, 5 - excellent image quality without artifacts). Gray-white matter differentiation will also be assessed analogous to Prakkamukal et al. (0 – no visible gray-white matter differentiation, 1 - unclear but recognizable borders, 2 - clear differentiation).

—

Countries

Germany

Contacts

Public ContactChristel Besseler

Klinik und Poliklinik für Radiologie Klinikum der Universität München Campus Großhadern

christel.besseler@med.uni-muenchen.de(089) 4400-73652

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026