I63
Conditions
Interventions
Group 1: The role of immunthrombosis as a predisposition factor for a cerebral infarction will be analysed.
Therefore, peripheral blood of patients with arterial occlusions of the ACI or ACM (identif
Sponsors
Universitätsklinikum BG Bergmannsheil GmbH, Abteilung für Neurochirurgie und -Traumatologie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Arm1: 1. patients with an acute occlusion of cranial arteries in the CTA, which implicate a neuroradiological intervention in form of a mechanical thrombectomy 2. Appearance of the stroke symptomatic within 6 hours prior to intervention Controls Arm2: Patients with degenerative stenosis of the lumbar spine, who are admitted to the Department of Neurosurgery and Neurotraumatology at the University Hospital Bergmannsheil Bochum.
Exclusion criteria
Exclusion criteria: 1. Pregnancy 2. Age 1Std. 4. cardiopulmonary reanimation in line with the symptomatic 5. Prove in CT of relevant pre-existing cerebral pathologies (previous stroke, past brainbleed, malignant tumor) 6. Hematological or autoimmune disease 7. Tumor 8. Usage of Cortison or Chemotherapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The role of immunthrombosis as a predisposition factor for a cerebral infarction will be analysed. For this purpose, the following points must be evaluated in particular: a) whether an irregular expression of immunthrombosis parameters, in particular NETs, predisposes peripheral blood with significantly higher rates of arterial occlusions of the ACI or ACM. For this purpose, the immunological profile in the peripheral blood of patients is compared with the controls. b) whether irregular activation or degradation of immune cells in the peripheral blood is also associated with a higher risk of acute occlusion of the ACI or ACM. For this purpose, the results of cell culture experiments in the peripheral blood of patients are compared with the controls. c) whether an irregular expression of immunthrombotic parameters and/or an irregular activation or degradation of immune cells in the peripheral blood and/or thrombus of patients correlates with the already known different stroke subtypes (according to TOAST classification) and thrombus subtypes (red, white, mixed). For this purpose, the immunological profile and results of cell culture experiments between the different subtypes of patients are compared | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) The role of immunthrombosis as a prognostic factor in patients with acute occlusion of ACI or ACM shall be analyzed. For this purpose, the following points must be evaluated in particular: (a) whether patients with different immunological profiles have different outcomes (early -day of discharge-; late - after 3 and 12 Months post intervention). (b) whether peri-interventional or subsequent complications are significantly different depending on the immunological profile of the patient. 2) For the first time, a characterization of the recovered thrombus with regard to expression and function of immunthrombosis parameters is aimed for. 3) In addition, it is investigated whether the histopathological/ immunological composition of the intra-arterial thrombus correlates with the intensity/leakage of the thrombus in the pre-interventional CTA. | — |
Countries
Germany
Contacts
Public ContactAngeliki Datsi (Deputy Principal Investigator)
Universitätsklinikum BG Bergmannsheil GmbH, Klinik für Neurochirurgie und -Traumatologie
Outcome results
None listed