Salivary secretion in Parkinson's Disease patients with and without deep brain stimulation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00013232

Enrollment

Registered

2017-11-13

Start date

2017-12-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G20 R68.2

Interventions

Group 1: PD (Parkinson's disease) patients with DBS (Deep Brain Stimulation) receive a salivation rate measurement and a masticatory function test via chewing gum in the medication-OFF Status (no med

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: • Patients with Parkinson's disease: after DBS (Deep Brain Stimulation) at least 3 months ago (Arm 1) or without DBS (Arm 2) • written informed consent • minimum 18 years old

Exclusion criteria

Exclusion criteria: • actual or planned pregnancy during the study • actual or anamnestic radiation or chemotherapy in the head/neck region • actual or anamnestic parotid tumor • actual or anamnestic surgery in the head/neck region • Sjögren-Syndrome • daily intake of symptom-relieving products against xerostomia, besides frequent water intake

Design outcomes

Primary

Measure	Time frame
Effect of Deep Brain Stimulation on salivation rates Therefore among Parkinson's disease patients with and without deep brain Stimulation in the Medication- OFF Status, there is Salivation amount measurement. Salivation rates is done by collecting all produced saliva for five minutes, afterwards saliva amount is measured. Finally the Stimulator is turned on again.	—

Secondary

Measure	Time frame
Effect of Dopamine on salivation rates, therefore, in the medication-OFF Status of Parkinson's disease patients without Deep Brain Stimulation, patients receive a standardized L-Dopa amount (200 mg), before and directly after salivation amounts are measured according to the primary endpoint. Masticatory function: participants chew 20 chewing cycles on two differently coloured chewing gums. Afterwards the degree of intermixing is documented by a specialized Software.	—

Measure

Time frame

Effect of Dopamine on salivation rates, therefore, in the medication-OFF Status of Parkinson's disease patients without Deep Brain Stimulation, patients receive a standardized L-Dopa amount (200 mg), before and directly after salivation amounts are measured according to the primary endpoint. Masticatory function: participants chew 20 chewing cycles on two differently coloured chewing gums. Afterwards the degree of intermixing is documented by a specialized Software.

—

Countries

Germany

Contacts

Public ContactGreta Barbe

Uniklinik KölnAbteilung für Zahnerhaltung und Parodontologie

anna.barbe@uk-koeln.de0221-478-96743

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026