From zero to one hundred: Longitudinal investigation on the impact of a regular exercise training on neuronal and functional brain plasticity.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00013211

Enrollment

Registered

2017-12-01

Start date

2009-02-03

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None (healthy participants)

Interventions

Group 1: Healthy, sedentary male participants without any regular exercise activity are exposed to three weekly sessions of cardiovascular training (running) over a period of six months, with a durati

Eligibility

Sex/Gender

Male

Age

40 Years to 65 Years

Inclusion criteria

Inclusion criteria: Healthy

Exclusion criteria

Exclusion criteria: Within the past two years: regular exercise training (at least once per week), sport club activities or daily physical activity related to personal transport (e.g. cycling). Neurological, psychiatric or cardiovascular diseases, left-handedness, MRI exclusion criteria.

Design outcomes

Primary

Measure	Time frame
MR-related changes over six months regarding brain structure, brain metabolism, brain activation patterns during pain processing, associative memory encoding, processing of emotional faces and executive control in a flanker paradigm.	—

Secondary

Measure	Time frame
Cardiovascular fitness before and after six months duration (VO2max, Blood Lactate Profile Curves); behavioural effects of pain perception, memory encoding, affect processing and executive control function.	—

Countries

Germany

Contacts

Public ContactHenning Boecker

Universitätsklinikum Bonn Radiologische Universitätsklinik Bonn FE Klinische Funktionelle Neurobildgebung

henning.boecker@ukbonn.de+49 (0) 228 287-15980

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026