Clinical and immunological outcome of two-piece zirconia-implants - a prospective randomized controlled clinical multicentre trial.

Clinical and immunological outcome of two-piece zirconia-implants - a prospective randomized controlled clinical multicentre trial. - Two-piece zirconia implants

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00013209

Enrollment

120

Registered

2017-11-21

Start date

2018-01-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Zirconia based dental implant

Interventions

Group 1: Two-piece zirconia implant Group 2: Two-piece titanium implant

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Only patients matching the following criteria will consecutively be included in the investigation: (i) Patients of 18 years or older who giving their informed, written consent; (ii) single tooth gaps with a sufficient amount of horizontal and vertical bone and soft tissue volume for the simultaneous placement of implants with a minimum length of 8 mm and a width of 4.1 mm including need for small transversal bony augmentation in terms of Guided Bone Regeneration (BioGide® membrane and BoneCeramic®); (iii) acceptance of the scheduled protocol of clinical and radiographic analysis and maintenance.

Exclusion criteria

Exclusion criteria: Excluded are all patients with any of the following criteria: (i) heavy smokers (> 10 cigarettes per day); (ii) signs of occlusal parafunctions (e.g. bruxers); (iii) present acute periodontal disease; (iv) lack of compliance or failure to give consent; (v) general contraindications against implant treatment or medication potentially compromising osseointegration (e.g. immunodeficiency, advanced systemic diseases, corticosteroid or bisphosphonate medication); (vi) pregnancy, assessed with a pregnancy test (HCG Schnelltest, DiaChrom bj-Diagnostik, Giessen, Germany); (vii) previous irradiation in the neck/head area.

Design outcomes

Primary

Measure	Time frame
Bone resorption after 1, 2 and 3 years in single radiographies	—

Secondary

Measure	Time frame
The occurence of complications and the concentration of aMMP8 around the implants	—

Countries

Austria, Switzerland

Contacts

Public ContactSebastian Kühl

Klinik für Zahnärztliche Chirurgie, -Radiologie, Mund- und Kieferheilkunde, Universitäres Zentrum für Zahnmedizin Basel

sebastian.kuehl@unibas.ch0041 61 2672611

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: May 30, 2026