Acute and chronic stress in Pruritus: influence on heart rate variability and quantitative sensoric testing

Acute and chronic stress in Pruritus: influence on heart rate variability and quantitative sensoric testing - Pruristress

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00013194

Enrollment

Registered

2017-10-23

Start date

2012-04-16

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

L29.8

Interventions

Group 1: Patients with chronic pruritus assess their stress Levels, their Pruritus intensity and desire to scratch by visual analogue scales (VAS) before and after a standardized social stress test, t

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with chronic Pruritus of the forearm

Exclusion criteria

Exclusion criteria: Exclusion criteria were Diabetes mellitus, polyneuropathia, neurologic diseases, chronic pain conditions, lesions or open wounds of the forearm, gravidity, skin infections, drug addiction, mental diseases, other dermatologic diseases, lidocaine allergy and marcumar. .

Design outcomes

Primary

Measure	Time frame
Perceived stress, heart rate variability and QST (Quantitative Sensory Testing). The acute stress perception is assessed by visual analogue scales (VAS) before and after a standardized social stress test (Trier Social Stress Test); heart rate variability is monitored by ECG; Quantitative Sensory Testing was performed with a QST-Kit. Chronic Stress Levels are assessed by the Trier Inventory for Chronic Stress (TICS), stressful childhood experiences by the Childhood Trauma Questionnaire (CTQ).	—

Measure

Time frame

Perceived stress, heart rate variability and QST (Quantitative Sensory Testing). The acute stress perception is assessed by visual analogue scales (VAS) before and after a standardized social stress test (Trier Social Stress Test); heart rate variability is monitored by ECG; Quantitative Sensory Testing was performed with a QST-Kit. Chronic Stress Levels are assessed by the Trier Inventory for Chronic Stress (TICS), stressful childhood experiences by the Childhood Trauma Questionnaire (CTQ).

—

Secondary

Measure	Time frame
Pruritus intensity, Intraepidermal nerve fiber density, associations to anxiety and Depression. Pruritus intensity is measured before and after the stress test by visual analogue scale; Intraepidermal nerve fiber density is assessed by biopsy, coloration and by microscope; anxiety and Depression are assessed by the Hospital Anxiety and Depression Scale (HADS).	—

Countries

Germany

Contacts

Public ContactGudrun Schneider

Klinik für Psychosomatik und Psychotherapie UKM

Gudrun.Schneider@ukmuenster.de0251-8352902

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026