Development and evaluation of an adaptive working memory training (WOME)

Development and evaluation of an adaptive working memory training (WOME) - DeWoMT

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00013162

Enrollment

Registered

2017-11-03

Start date

2013-03-12

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F06.7

Interventions

Group 1: WOME adaptive working memory training (intervention Group) 3x45 min/week over 4 weeks (12 sessions overall) Group 2: placebo intervention group (low level working memory training at a fixed l

Eligibility

Sex/Gender

All

Age

60 Years to 75 Years

Inclusion criteria

Inclusion criteria: fluent in German, clinically healthy, willingness and ability to take part in the outcome measurements (incl. MRI) and in the intensive training program

Exclusion criteria

Exclusion criteria: history of neurological and/or psychiatric disease, severe cognitive deficits, alcohol or drug abuse, participation in other cognitive enhancement programs

Design outcomes

Primary

Measure	Time frame
Primary Outcome is working memory functioning. Performance is analyzed with multiple standardized neuropsychological tests. A recent meta-analysis showed that the Span Board task backwards is the most sensitive variable to assess changes in working memory, therefore it was chosen as a criterion task. Further outcome measures regarding working memory are: Digit and Span Board tasks (WMS-R), Spatial Addition and Symbol Span (WMS-IV), n-back Aufgabe (TAP), Operation Span Task, PASAT (Paced Auditory Serial Addition Test). All outcomes are measured 3 times: pre/post intervention as well as at a 3-month follow-up. Examinations are individual and take place in quite separate rooms. The examiners are blind with respect to group allocation.	—

Measure

Time frame

Primary Outcome is working memory functioning. Performance is analyzed with multiple standardized neuropsychological tests. A recent meta-analysis showed that the Span Board task backwards is the most sensitive variable to assess changes in working memory, therefore it was chosen as a criterion task. Further outcome measures regarding working memory are: Digit and Span Board tasks (WMS-R), Spatial Addition and Symbol Span (WMS-IV), n-back Aufgabe (TAP), Operation Span Task, PASAT (Paced Auditory Serial Addition Test). All outcomes are measured 3 times: pre/post intervention as well as at a 3-month follow-up. Examinations are individual and take place in quite separate rooms. The examiners are blind with respect to group allocation.

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Secondary

Measure	Time frame
Secondary outcomes are cognitive functions that partially rely on working memory capacity (exekutive functions, logic reasoning, long-term memory) as well as transfer on everyday life. Performance of cognitive functioning is analyzed with multiple standardized neuropsychological tests (exekutive functions: Stroop-Test, TMT (Trail Making Test), TAP Flexibility/Go-Nogo; logic reasoning: LPS-3; -term memory: VLMT (verbal learning and memory test)), transfer on everyday life is measured by standardized questionnaires (FEAG (Fragebogen zur Erfassung alltäglicher Gedächtnisleistungen) , CFQ (Cognitive Failure Questionnaire)) and self-reports. In order to examine specifitiy of the training, a reaction time task was included as well (TAP Alertness). An investigation of functional (resting state, task-fMRI) and structural (T1) data of the brain is investigated by MRI. All outcomes are measured 3 times: pre/post intervention as well as at a 3-month follow-up. Examinations are individual and take place in quite separate rooms. The examiners are blind with respect to group allocation.	—

Measure

Time frame

Secondary outcomes are cognitive functions that partially rely on working memory capacity (exekutive functions, logic reasoning, long-term memory) as well as transfer on everyday life. Performance of cognitive functioning is analyzed with multiple standardized neuropsychological tests (exekutive functions: Stroop-Test, TMT (Trail Making Test), TAP Flexibility/Go-Nogo; logic reasoning: LPS-3; -term memory: VLMT (verbal learning and memory test)), transfer on everyday life is measured by standardized questionnaires (FEAG (Fragebogen zur Erfassung alltäglicher Gedächtnisleistungen) , CFQ (Cognitive Failure Questionnaire)) and self-reports. In order to examine specifitiy of the training, a reaction time task was included as well (TAP Alertness). An investigation of functional (resting state, task-fMRI) and structural (T1) data of the brain is investigated by MRI. All outcomes are measured 3 times: pre/post intervention as well as at a 3-month follow-up. Examinations are individual and take place in quite separate rooms. The examiners are blind with respect to group allocation.

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Countries

Germany

Contacts

Public ContactJuliane Weicker

Tagesklinik für Kognitive Neurologie, Universitätsklinikum Leipzig

weicker@cbs.mpg.de+493419724991

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 23, 2026