F05
Conditions
Interventions
Group 1: The acupuncture is carried out as standardized by the same investigator. The performing physician, Dr. med. Sven Asmussen, received the acupuncture diploma of the CBIATC (Chinese Beijing Inte
Sponsors
Universitätsklinikum Knappschaftskrankenhaus Bochum, Universitätsklinikum der Ruhr-Universität Bochum
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients scheduled for total endoprothetic hip Joint replacement were included
Exclusion criteria
Exclusion criteria: o Age <65 years o Pre-existing dementia o immunosuppression o Chronic skin diseases o Rejection by patients o Previous participation in this study o Drugaddicted patients , psychosis o Patients with heart pacemaker and deep brain stimulation o Existing anticholinergic medication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium after total hip joint replacement Preoperative, when transferred from the recovery room and 24 h and 48 h postoperatively, the Delire estimation is performed according to the "Confusion Assessment Method" for intensive care units (CAM-ICU) | — |
Secondary
| Measure | Time frame |
|---|---|
| o Activity of acetylcholineestrase (ACHE) and butyrylcholinesterase (BCHE) in the blood o Determination TNFa, NSE, S-100 ß protein o Epigenetic markers such as DNA methylation, acetylation, and histone modifications o Hospital lenght of stay These analyses are made at 4 times (during premedication, directly postoperatively, first and second postoperative day) with 15 ml of venous whole blood. | — |
Countries
Germany
Contacts
Public ContactLars Bergmann
Universitätsklinikum Knappschaftskrankenhaus Bochum, Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie
Outcome results
None listed