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CT Angiography of the Aorta: Prospective Evaluation of an Individualized Low-Radiation Dose and Low-Volume Contrast Media Protocol with Dual-Energy CT for Detection of Endoleaks after Endovascular Aneurysm Repair

CT Angiography of the Aorta: Prospective Evaluation of an Individualized Low-Radiation Dose and Low-Volume Contrast Media Protocol with Dual-Energy CT for Detection of Endoleaks after Endovascular Aneurysm Repair

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00013082
Enrollment
500
Registered
2017-11-03
Start date
2017-10-24
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

CT angiography of the aorta I71

Interventions

Group 1: CT scan using an optimized and individualized low radiation dose and low iodine protocol, depending on the clinical indication with native, arterial and delayed phase.

Sponsors

Universitätsklinikum Heidelberg
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1) Clinically indicated CTA (CT Angiography) of the aorta without ECG-triggering, before or after aortic repair. 2) Informed written consent to participate in the study as well as consent to the scientific evaluation of the data.

Exclusion criteria

Exclusion criteria: 1) Severe allergic reactions to iodine-based contrast agents if other imaging methods are possible. 2) Highly restricted renal function (eGFR < 20 mL/min) in patients who are currently not dependent upon dialysis if other imaging procedures are possible. 3) Planned radioiodine therapy or suspicion of thyroid tumors. 4) Pregnancy. 5) Emergency patients. 6) Patients with acute psychosis or other conditions that limit their understanding. 7) Patients who cannot lie still. 8) Patients with history of high grade cardiac insufficiency (NYHA Class III or IV).

Design outcomes

Primary

MeasureTime frame
Contrast (measured in Hounsfield units) of the CTA (computer tomographic angiography) using the individualized low-dose protocol.

Secondary

MeasureTime frame
Detection rate of endoleaks using a biphasic dual-energy CT protocol (arterial phase single-energy, delayed phase dual-energy) including the virtual native phase reconstructed from the delayed phase compared to the triphasic CT protocol (native, arterial and delayed phase).

Countries

Germany

Contacts

Public ContactMatthias A. Fink

Diagnostische und Interventionelle Radiologie Universitätsklinikum Heidelberg

matthias.fink@uni-heidelberg.de+49 6221 56 6110

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026