Healthy volunteers
Conditions
Interventions
Group 1: Experimental - Cognitive training Group:
Group undergoing cognitive training, repeated neuropsychological testing (prior to the cognitive Training, immediately after the cognitive Training,
see arm cog.+physical training group). Subjects recruited at the centers University Medical Center Mainz and University Rostock will only receive cognitive training (see arm cog. training group). To a
Sponsors
Klinik für Psychiatrie und Psychotherapie, Universitätsmedizin Mainz
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: Age = 60 years; Ability of subject to understand character and individual consequences of clinical Trial; Signed and dated informed consent must be available before start of any procedures; Sufficient mobility and motivation to be able to participate in the examinations
Exclusion criteria
Exclusion criteria: Incapability of giving consent; Current (or history of) psychiatric illness; Current (or history of) neurological or cerebrovascular illness; Current (or history of) cardiovascular disease (i.e. myocardial infarct, peripheral arterial disease); Secondary disorders restricting individuals’ physical capacity (i.e. COPD, rheumatism, osteoarthritis, bone fractures); Current (or history of) cognitive illness; Diabetes Type 1 and 2; Intake of medications that may influence cognitive performance; Insufficient German language skills; Participation in other clinical trials during the present clinical trial or within the last 1 month; MRI contraindication (pacemaker, metal implants, tattoos, permanent-make-up, cochlear implant, medication pump, acupuncture needles)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Training gain transfer, quantified by a dichotomous variable. Successful transfer will be defined in line with our publication Wolf et al. (2014).HBM,35:309-318: (i) Performance improvement in a logical reasoning training task from the second to the last training session and (ii) performance improvement in an untrained fluid intelligence transfer task from the pre-cognitive training phase to the post-cognitive training phase and (iii) maintenance of the performance in the transfer task from post-cognitive training phase to follow-up. Transfer task performance alterations have to be numerically greater than the mere retest-effect of an untrained control group. Since both the neuropsychological examination and the neuropsychological training include more tasks than the two tasks of the primary endpoint, training gain transfer from other training tasks to other transfer tasks will be investigated within the secondary objectives. | — |
Secondary
| Measure | Time frame |
|---|---|
| Structural integrity of the corpus callosum - quantified using Diffusion-Tensor-Imaging, Default mode network activity - quantified using resting-state fMRI, Brain derived neurotrophic factor - quantified using blood samples, Motor Fitness - quantified using a test battery comprising several motor tasks, VO2max - quantified using a graded maximal exercise test on the treadmill. Endpoints will be measured prior to the physical training and prior to the cognitive training. | — |
Countries
Germany
Contacts
Public ContactBianca Kollmann
Universitätsmedizin Mainz, Klinik für Psychiatrie und Psychotherapie
Outcome results
None listed