Influence of non-invasive electrical brain stimulation on explicit learning of a visuomotor fine motor task

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00013044

Enrollment

144

Registered

2017-10-02

Start date

2017-10-04

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

visuomotor learning

Interventions

Group 1: Arm 1 - Sequence-unspecific training: randomised paradigm with sham-tDCS (tDCS = transcrananial direct current stimulation) (Training 1 + placebo). The singular training day includes a hand m

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: Age between 18 and 85 years, explicit dominance of handedness (left- or right-hander according to Edinburgh Handedness Inventory 1971)

Exclusion criteria

Exclusion criteria: Severe chronic neurologic or psychiatric previous illness in anamnesis, current neurologic or psychiatric illness, not-corrigible defective vision, limited mobility of the upper extremity. Participants > 40 years: 24 or less points in the mini-mental-status test (MMSE), implanted medical devices (eg cochlear implant) or ferromagnetic objects (eg vascular clamps) in head and neck region.

Design outcomes

Primary

Measure	Time frame
Learning success at the end of the training day (day 1), measured as difference in reaction time and motor skill before, during and after Training, when performing the SVIPT paradigm (SVIPT = sequential visual isometric pinch force task). This will be measured for explicit learning (randomised training blocks) as well as implicit learning (last sequential training block compared to last random block).	—

Measure

Time frame

Learning success at the end of the training day (day 1), measured as difference in reaction time and motor skill before, during and after Training, when performing the SVIPT paradigm (SVIPT = sequential visual isometric pinch force task). This will be measured for explicit learning (randomised training blocks) as well as implicit learning (last sequential training block compared to last random block).

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Secondary

Measure	Time frame
Single and group level analysis of secondary data: psychophysical data quantified daily (Days 1, 2 and 30) by standardized questionnaires Positive and Negative affect scale PANAS / Beck Depression inventory BDI as well as visual analogue scales for attention and subjective affection. MRI: structural data acquired once within the 30 days of participation in the study. Blood sampling for singular genetic analysis of polymorphisms in the gene for BDNF, COMT and ApoE. All parameters will be associated with the primary outcome, either by correlation or by their influence in a statistical regression model.	—

Measure

Time frame

Single and group level analysis of secondary data: psychophysical data quantified daily (Days 1, 2 and 30) by standardized questionnaires Positive and Negative affect scale PANAS / Beck Depression inventory BDI as well as visual analogue scales for attention and subjective affection. MRI: structural data acquired once within the 30 days of participation in the study. Blood sampling for singular genetic analysis of polymorphisms in the gene for BDNF, COMT and ApoE. All parameters will be associated with the primary outcome, either by correlation or by their influence in a statistical regression model.

—

Countries

Germany

Contacts

Public ContactJanine Reis

Universitätsklinikum Freiburg, Klinik für Neurologie und Neurophysiologie

janine.reis@uniklinik-freiburg.de0761-270-50010

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026