Longitudinal characterization of circulating DNA in serum of patients after allogenic bone augmentation

Conditions

Patients in need of bone augmentation prior dental implant placement

Solakoglu Ö, Götz W, von Baehr V, Heydecke G, Pantel K, Schwarzenbach H.

2022-12-103 citations

A 3-year prospective randomized clinical trial of alveolar bone crest response and clinical parameters through 1, 2, and 3 years of clinical function of implants placed 4 months after alveolar ridge preservation using two different allogeneic bone-grafting materials.

Solakoğlu Ö, Ofluoğlu D, Schwarzenbach H, Heydecke G, Reißmann D, Ergun S, Götz W.

2022-02-019 citations

10.1186/s40729-022-00402-w

Interventions

Group 1: Bone augmentation withautogenic bone graft from intraoral donor site Group 2: Bone augmentation with allogenic bone graft (maxgraft granules, botiss biomaterials GmbH). The clinical effect o

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: self reported healthy, between 18 and 85 years old. Patients requiring intraoral bone augmentation prior to implantation with dental implants.

Exclusion criteria

Exclusion criteria: under 18 years old

Design outcomes

Primary

Measure	Time frame
Measurement of DNA in the serum of patients who have received allogenic bone replacement material at 4 times: T1: preoperative T2: immediately postoperative T3: 5 weeks postoperatively T4: 4 months postoperatively Measurement is performed by real time PCR and gel electrophoresis.	—

Secondary

Measure	Time frame
Furthermore, the DNA is assessed quantitatively and qualitatively. Exosomes are detected and measured, as well as mRNA.	—

Countries

Germany

Contacts

Public ContactÖnder Solakoglu

Fachpraxis für Parodontologie und Implantologie

info@fpi-hamburg.de+49 (0) 40 51 50 50

Outcome results

None listed