The Role of the Temporo-parietal Junction in Functional Neurological Disorders. A Study with Transcranial Magnetic Stimulation and Mindfulness Therapy.

The Role of the Temporo-parietal Junction in Functional Neurological Disorders. A Study with Transcranial Magnetic Stimulation and Mindfulness Therapy. - TPJ in FND

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00012992

Enrollment

556

Registered

2017-09-08

Start date

2017-09-11

Completion date

Unknown

Last updated

2025-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F44

Interventions

Group 1: Real TMS over the right TPJ in FND patients and healthy controls Group 2: Sham TMS over the right TPJ in FND patients and healthy controls Group 3: 8-weeks MBSR (Mindfulness-based Stress Redu

Eligibility

Sex/Gender

All

Age

16 Years to No maximum

Inclusion criteria

Inclusion criteria: FND patients, organic controls, and healthy controls • Aged > 16 years old • Capable of judgement • Willing to participate in the study (by signing the informed consent form)

Exclusion criteria

Exclusion criteria: - Presence of comorbid disorders such as psychosis or major depression with suicidal risk - Presence of metal clips in the body - For female participants: breastfeeding, pregnancy or intention to become pregnant - Epilepy

Design outcomes

Primary

Measure	Time frame
•Performance on a behavioural task (T1, T2, T3, T4) •Performance on an objective measurement of muscle strength (T1, T2, T3, T4) •Subjective assessment of own agency (T1, T2, T3, T4) •The fMRI measures of blood oxygenation in the right TPJ during the behavioural task (T1, T2,T3,T4) • Stress parameters (T3, T4) • Performance of FND patients and organic controls on neurological bedside tests T1: before TMS T2: after TMS T3: before MBSR T4: after MBSR T5: during clinical bedside testing	—

Measure

Time frame

•Performance on a behavioural task (T1, T2, T3, T4) •Performance on an objective measurement of muscle strength (T1, T2, T3, T4) •Subjective assessment of own agency (T1, T2, T3, T4) •The fMRI measures of blood oxygenation in the right TPJ during the behavioural task (T1, T2,T3,T4) • Stress parameters (T3, T4) • Performance of FND patients and organic controls on neurological bedside tests T1: before TMS T2: after TMS T3: before MBSR T4: after MBSR T5: during clinical bedside testing

—

Secondary

Measure	Time frame
•The fMRI measures of blood oxygenation in brain areas other than the right TPJ (T1, T2, T3, T4) •Score of a questionnaire about acceptance of TMS as a possible treatment for FND (T2) •Score of a questionnaire about acceptance of MBSR as a possible treatment for FND (T4) • Stress parameters and the (epi-) genetic profile in FND patients and healthy controls (T3) • Long-term fluctuations in FND symptoms (T3 + 6 months) T1: before TMS T2: after TMS T3: before MBSR T4: after MBSR T5: during clinical bedside examination	—

Measure

Time frame

•The fMRI measures of blood oxygenation in brain areas other than the right TPJ (T1, T2, T3, T4) •Score of a questionnaire about acceptance of TMS as a possible treatment for FND (T2) •Score of a questionnaire about acceptance of MBSR as a possible treatment for FND (T4) • Stress parameters and the (epi-) genetic profile in FND patients and healthy controls (T3) • Long-term fluctuations in FND symptoms (T3 + 6 months) T1: before TMS T2: after TMS T3: before MBSR T4: after MBSR T5: during clinical bedside examination

—

Countries

Switzerland

Contacts

Public ContactSelma Aybek

Department of Neurology,University of Fribourg

selma.aybek@unifr.ch+41 26 306 38 02

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 18, 2026