Change in olfactory perception during psychotherapeutic treatment of patients with depressive disorder

Change in olfactory perception during psychotherapeutic treatment of patients with depressive disorder - COPD

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00012970

Enrollment

Registered

2017-10-24

Start date

2017-10-12

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F32 F33

Interventions

Group 1: The olfactory perception (perception threshold, discrimination, identification) of Patients with depressive disorder will be examined at three time points (before the start of a psychotherap

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patient sample: Depressive disorder as primary diagnosis, participation in cognitive behavioral therapy Control group: healthy volunteers

Exclusion criteria

Exclusion criteria: Patients: Drug or substance abuse, permanent use of medication (exception: oral contraceptives or occasional use of headache tablets up to one week before the beginning of the study, prescribed psychopharmaceuticals) Control group: Mental disorder, drug or substance abuse, permanent administration of medications (exception: oral contraceptives or occasional use of headache tablets up to one week before the start of the study)

Design outcomes

Primary

Measure	Time frame
Examination of the presence of deficits in olfactory perception (perception threshold, discrimination, identification) in patients with depression compared to a healthy control group adjusted for age and sex. The olfactory perception is measured in all dimensions with the Sniffin 'Sticks. Change of the olfactory perception (perception threshold, discrimination, identification) in the course of the therapy. Predictability of the change in symptom stress, recorded by the BDI, in the course of the therapy based on the olfactory perception. Three survey days: 1) before the start of therapy (during or after the probatory sessions), 2) after the 12th therapies session, 3) after the 24th therapies session.	—

Measure

Time frame

Examination of the presence of deficits in olfactory perception (perception threshold, discrimination, identification) in patients with depression compared to a healthy control group adjusted for age and sex. The olfactory perception is measured in all dimensions with the Sniffin 'Sticks. Change of the olfactory perception (perception threshold, discrimination, identification) in the course of the therapy. Predictability of the change in symptom stress, recorded by the BDI, in the course of the therapy based on the olfactory perception. Three survey days: 1) before the start of therapy (during or after the probatory sessions), 2) after the 12th therapies session, 3) after the 24th therapies session.

—

Secondary

Measure	Time frame
Diagnostic Interview using SKID. Examination of the correlation between olfactory performance and the severity of comorbidities like e.g. anxiety disorders (BSI).	—

Countries

Germany

Contacts

Public ContactChristian Schanz

Universität des SaarlandesKlinische Psychologie und Psychotherapie

christian.schanz@uni-saarland.de++49 +681 302 71005

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026