Influence of benzodiazepines and propofol on epigenetic modifications in immune cells and their influence on postoperative cognitive dysfunction

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00012961

Enrollment

Registered

2018-06-19

Start date

2017-05-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy subjects

Interventions

Group 1: After written informed consent, 90 ml of venous whole blood is collected in EDTA monovettes from 20 healthy volunteers. This is stimulated with different anesthetics (propofol, midazolam, oth

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: healthy, no infection

Exclusion criteria

Exclusion criteria: infection, anemia

Design outcomes

Primary

Measure	Time frame
Understanding the pathophysiology of POCD by measuring the expression of enzymes that regulate epigenetic mechanisms after stimulating whole blood samples with different anesthetics. Analysis of epigenetic markers such as DNA methylation, acetylation and histone modifications after anesthetic stimulation.	—

Secondary

Measure	Time frame
developement of biomarkers for POCD.	—

Countries

Germany

Contacts

Public ContactKatharina Rump

Ruhr Universität Bochum Knappschaftskrankenhaus Bochum Klinik für Anästesiologie

katharina.k.rump@rub.de02343229242

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026