Examination, validation and translation of signaling networks of cellular radiation response

Examination, validation and translation of signaling networks of cellular radiation response - ZiSStrans

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00012947

Enrollment

150

Registered

2019-06-04

Start date

2017-09-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C10 C13 C32

Interventions

Group 1: Collecting clinical patient data

Oral Mucositis Assessment

oral mucosa biopsy

samples of resting saliva and sample of serum before radiochemotherapy

preparation of biological materials: proteome analysis of saliva, cell culture of keratinocytes, in vitro testing of radiation sensitivity, microRNA analyses of serum samples

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Histologically confirmed carcinoma of the oral cavity, the oropharynx, hypopharynx or larynx; planned radiation therapy in the head-neck-area according to a standardized protocol (cisplatin-based radiochemotherapy, radiation dose 60-70 Gy, fractionation 5 x 2 Gy / week); written consent

Exclusion criteria

Exclusion criteria: Complete removal of major salivary glands in the context of surgical tumor therapy

Design outcomes

Primary

Measure	Time frame
Prediction of individual, i.e. patient-specific side effects and tumor control during / after radiation therapy	—

Countries

Germany

Contacts

Public ContactElsa Beatriz Monroy Ordonez

Universitätsklinikum Freiburg, Klinik für Strahlenheilkunde

beatriz.monroy@uniklinik-freiburg.de+49 761 270-94630

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026