J84
Conditions
Interventions
Group 1: Fibrosis patients with whole body vibration training over 3 months, 3 training days with 3x3 minutes increasing intensity (Hz).
Group 2: Fibrosis patients with Sham Training (WBV) over 3 mont
Sponsors
Universitätsklinikum Gießen und Marburg GmbHZentrum für Innere Medizin Schwerpunkt Pneumologie
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria were: the diagnoses of ILD, idiopathic pulmonary fibrosis (IPF), Idiopathic nonspecific interstitial pneumonia (NSIP), acute interstitial pneumonia (AIP), Cryptogenic organizing pneumonia (COP) or Sarcoidosis, written informed consent.
Exclusion criteria
Exclusion criteria: - no pulmonary fibrosis - sarcoidosis - withdrawn consent - Indication of acute pathological cardiac events in the laboratory or ECG (TNI or CK increase, new ST segment changes). - Concomitant diseases such as heart failure (NYHA III and IV) or COPD - decompensated cardiac insufficiency - high blood pressure (>220/120 mmHg) - more serious mental illnesses - cognitive limitations - Restrictions of the musculoskeletal system that make training with the Galileo impossible: ? Acute thrombosis ? Implants in trained body regions ? Acute Arthrosis ? Acute tendinopathy ? Acute hernia ? Acute discopathy ? Fresh Fractures ? Fresh wounds and/or scars - neurological diseases that affect training and performance - acute exacerbations in the last 3 months - acute inflammation/infections up to 4 weeks before inclusion - Change in antifibrotic therapy in the last 3 months or participation in a lung sport
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measuring the performance of the patients based on the % of modification of 6 minutes walking distance after 3 months in comparison to the baseline study and the Sham-training control group. The investigations took place at the time of enrollment (t0) and after 3 months (t1). | — |
Secondary
| Measure | Time frame |
|---|---|
| - Patients have a muscular performance advantage through targeted training with the Galileo compared to the Sham Training Control Group (Tests: Chair Rising Test: 5 times standing up from a chair). - Whether the quality of life and the degree of depression are different in the two groups studied (SF-36, HADS, UCSD-SOB (dyspnoea scale)). - Whether patients have a less strongly reduced muscle cross-section of the muscles of the quadriceps femoris muscle by comparison with the control group. - Whether patients lose their pulmonary function after training, compared with the control group (VC, FVC, DLCO) - Whether patients under exercise therapy show more reduced inflammation parameters (serum IL-1, -6, -8, TNF-alpha, FGF, BNP) compared to the control group. - Whether patients under the training therapy have more changed laboratory parameters in the form of iris, MMP-9, TIMP-1, myostatin, telomere lengths (senescence parameters) and PGC1a than the Sham training control group (evaluation takes place in Marburg) | — |
Countries
Germany
Contacts
Public ContactAndreas Rembert Koczulla
Universitätsklinikum Gießen und Marburg GmbHZentrum für Innere Medizin Schwerpunkt Pneumologie
Outcome results
None listed