Influences of different nicotine applications on peripheral and central hemodynamic as well as on arterial stiffness and endothelial dysfunction

Influences of different nicotine applications on peripheral and central hemodynamic as well as on arterial stiffness and endothelial dysfunction - EZig

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00012919

Enrollment

Registered

2017-08-29

Start date

2016-06-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Smoker healthy volunteers I70.9

Interventions

Group 1: e-cigarette with nicotine (24 mg/ml) Group 2: filter cigarette (nicotine - 0.7 mg) Group 3: e-cigarette without nicotine

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: - age over 18 years - active smoking - written consent to the study protocol - female smokers under oral contraceptives (to avoid hormonal/cyclic dependencies)

Exclusion criteria

Exclusion criteria: - non smoking - pregnancy or lactation - drug or alcohol abuse - participation in other clinical trials - lack of compliance

Design outcomes

Primary

Measure	Time frame
The primary outcome is the measurement of the nicotine concentration in the blood ten minutes after the nicotine application and during follow-up after one and two hours as well as the changes in blood pressure.	—

Secondary

Measure	Time frame
Secondary outcomes include changes in peripheral and central hemodynamics, arterial stiffness, endothelias dysfunction and inflammatory markers depending on the various nicotine applications for two hours after vaping e.g. smoking.	—

Countries

Germany

Contacts

Public ContactKlaas F. Franzen

Universitätsklinikum Schleswig-Holstein Campus Lübeck

klaas.franzen@uksh.de+49 451 500 45003

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026