Olfactory dysfunction R43.0
Conditions
Interventions
Group 1: Patients with ideophathic smell loss or after rhininasal infection: 3 time points (every 12 weeks): MRI / fecal and nasal mircobiome samples
Group 2: Healthy subjects: 3 measurement time poin
Sponsors
Universität Graz
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Patients with olfactory dysfunction after traumatic brain injury, due to ideopathic or postviral infection; healthy subjects
Exclusion criteria
Exclusion criteria: Cardiovascular diseases, pulmonary diseases, nosebleeding within the last three days, chronic respiratory diseases, central nervous diseases, diseases affecting the cerebral metabolism, metallic implants, claustrophobia, pregnancy, neurological or psychiatric disorders, drug abuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Investigation of neuroplasticity (fMRI) - in patients with ideopathic smell dysfunction or after rhinosinusitis vs. healthy subjects vs. patients with smell dysfunction after TBI (traumatic brain injury) (at time point 1) - in patients with ideopathic smell dysfunction or after rhinosinusitis vs. healthy subjects (at time point 2, after 12 weeks) - in patients with ideopathic smell dysfunction or after rhinosinusitis vs. healthy subjects (at time point 3, after 24 weeks) | — |
Secondary
| Measure | Time frame |
|---|---|
| Definition of biomarkers using microbiome measures in connection to olfactory dysfunction as an additional variable to explain neuroplastic alterations (fMRI) | — |
Countries
Austria
Contacts
Public ContactFlorian Fischmeister
Universität Graz
Outcome results
None listed