M06.9
Conditions
Interventions
Group 1: chronic pain patients
Tests: neuro-psychological tests, number sense tests, ECG, pulseoxymetry, MRI and fMRI
Group 2: healthy controls
Tests: neuro-psychological tests, number sense tests, E
Sponsors
Universitätsklinikum für Anästhesiologie, Intensiv-, Notfallmedizin und SchmerztherapieKlinikum Oldenburg AöR
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: All: 18 years of age or older, fluid in German, right handedness, Pain group: chronic-rheumatic joint disease; more than 6 months of pain Controls: no pain
Exclusion criteria
Exclusion criteria: Refusal to participate, missing consent, MRI contraindicated, Body weight: >130kg, Age: >75 years, inability to lie flat and still, pregnancy, alcohol and/ or drug abuse (present or in history), known dyscalculia, idiopathic back pain, neurological disease (dementia, epilepsy, migraine, strong recurrent headaches, Parkinson’s disease, multiple sclerosis, myasthenia gravis, meningitis, neurodegenerative disease, head or cerebral trauma, cerebro-vascular disease, , stroke, severe asthma, severe COPD, heart failure (>NHHA II), history of heart surgery, peripheral vascular disease, implanted pacemaker or Defibrillator, kidney failure, dialysis, chronic liver disease (hepatitis, liver failure), cancer (present or in history), acute infectious disease (HIV, tuberculosis), decompensated thyroid disease, history of psychiatric disease (schizophrenia, major depression, borderline personality disorder)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| a) Clinical: Comparison of number sense between Groups employing numberline tasks b) Cerebral functional: characterization of brain activity patterns after stimulation of number sense using fMRI c) Anatomical: Measurement of gray matter density using MRI and voxel-based morphometry | — |
Secondary
| Measure | Time frame |
|---|---|
| a) Clinical: comparison of heart rate variability between Groups employing ECG analysis b) Cerebral functional: characterization of activity patterns in autonomic brain regions (insular cortex) using fMRI | — |
Countries
Germany
Contacts
Public ContactMelanie Spindler
AG Biologische Psychologie, Institut für Psychologie, Fakultät 6,Carl von Ossietzky Universität Oldenburg
Outcome results
None listed