G35
Conditions
Interventions
Group 1: Patients will be randomised to two Treatment Groups receiving active and sham Treatment in a cross-over design. One Group ist receiving active-->sham, the other sham-->active. Active Treatmen
Sponsors
Psychiatrische Klinik
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: - Right handed patients - Definite Multiple Sclerosis diagnosis according to the 2010 McDonald criteria - Fatigue since more than 6 months as assessed by fatigue severity scale (FSS>5) - Age between 18 and 75 years. - Stable pharmacological and physical treatment since at least one month
Exclusion criteria
Exclusion criteria: - Relapses within the last two months - Expanded disability status scale = 6.5 - Severe depression based on Beck Depression inventory (BDI>19) - Daytime sleepiness based on Epworth Sleepiness Scale (ESS> 11) - Other neurologic and psychiatric diseases
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Improvement of mood (Hospital anxiety and Depression Scale) in the active group compared to sham group after 5 treatments. Improvement of sleep quality and mobility after active stimulation. Improvement of emotion recognition after active stimulation. | — |
Primary
| Measure | Time frame |
|---|---|
| Improvement of cognition and working memory(2-back test, Symbol Digit modalities test), and fatigue (fatigue severity scale, modified fatigue Impact scale) in the active group compared to sham group after 5 treatments. | — |
Countries
France, Germany
Contacts
Public ContactUlrich Palm
Psychiatrische Klinik
Outcome results
None listed