Body representation and sensorimotor function as agents for brain reorganization and behavior change: from chronic pain to immobility and dementia

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

DRKS

Registry ID

DRKS00012748

Enrollment

260

Registered

2017-07-13

Start date

2017-08-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic musculoskeletal pain

Interventions

Group 1: Experimental condition 1. 80 students: Virtual mirror training after artificial immobilization of one arm by wearing an orthosis (two weeks of daily training) 2. 60 subjects with chronic musc

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Presence of group membership (chronic musculoskelettal pain; mild cognitive impairment; injury-induced immobilization; absence of these factors = healthy controls)

Exclusion criteria

Exclusion criteria: MRI exclusion criteria, subjects unable to consent, pregnancy, current mental disorder

Design outcomes

Primary

Measure	Time frame
1. Student group: before training - after training (after 2 weeks), resp. experimental condition - control condition; sensorimotor changes (strength measurement) 2. Subjects with chronic musculoskelettal pain: before training - after training (after 12 weeks), resp. experimental condition - control condition; changes in pain level (multidimensional pain inventory) 3. Subjects with mild cognitive impairment: before training - after training (after 12 weeks), resp. experimental condition - control condition; changes in cognitive performance (Montreal Cognitive Assessment, CANTAB) 4. Subjects with injury-induced immobilization: experimental condition - control condition; degree of sensorimotor deficits (strength measurement, sensory thresholds; only after immobilization)	—

Measure

Time frame

1. Student group: before training - after training (after 2 weeks), resp. experimental condition - control condition; sensorimotor changes (strength measurement) 2. Subjects with chronic musculoskelettal pain: before training - after training (after 12 weeks), resp. experimental condition - control condition; changes in pain level (multidimensional pain inventory) 3. Subjects with mild cognitive impairment: before training - after training (after 12 weeks), resp. experimental condition - control condition; changes in cognitive performance (Montreal Cognitive Assessment, CANTAB) 4. Subjects with injury-induced immobilization: experimental condition - control condition; degree of sensorimotor deficits (strength measurement, sensory thresholds; only after immobilization)

—

Secondary

Measure	Time frame
1. Student group: before training - after training, resp. experimental condition - control condition; cortical organisation of sensorimotor brain areas (fMRI) 2. Subjects with chronic musculoskelettal pain: before training - after training, resp. experimental condition - control condition; quality of life (SF-36) 3. Subjects with mild cognitive impairment: before training - after training, resp. experimental condition - control condition; biomarkers, e.g., Tau proteins 4. Subjects with injury-induced immobilization: experimental condition - control condition; reconvalescence time	—

Measure

Time frame

1. Student group: before training - after training, resp. experimental condition - control condition; cortical organisation of sensorimotor brain areas (fMRI) 2. Subjects with chronic musculoskelettal pain: before training - after training, resp. experimental condition - control condition; quality of life (SF-36) 3. Subjects with mild cognitive impairment: before training - after training, resp. experimental condition - control condition; biomarkers, e.g., Tau proteins 4. Subjects with injury-induced immobilization: experimental condition - control condition; reconvalescence time

—

Countries

Germany

Contacts

Public ContactStefano Silvoni

Institut für Neuropsychologie und Klinische Psychologie Zentralinstitut für Seelische Gesundheit

stefano.silvoni@zi-mannheim.de0621-17036303

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 20, 2026